An explicit transition density expansion for a multi-allelic Wright-Fisher diffusion with general diploid selection

DOI10.1016/J.TPB.2012.10.006zbMATH Open1275.92090arXiv1208.5087OpenAlexW3101304556WikidataQ43226972 ScholiaQ43226972MaRDI QIDQ383299FDOQ383299

Authors: Matthias Steinrücken, Y. X. Rachel Wang, Yun S. Song 

Publication date: 25 November 2013

Published in: Theoretical Population Biology (Search for Journal in Brave)

Abstract: Characterizing time-evolution of allele frequencies in a population is a fundamental problem in population genetics. In the Wright-Fisher diffusion, such dynamics is captured by the transition density function, which satisfies well-known partial differential equations. For a multi-allelic model with general diploid selection, various theoretical results exist on representations of the transition density, but finding an explicit formula has remained a difficult problem. In this paper, a technique recently developed for a diallelic model is extended to find an explicit transition density for an arbitrary number of alleles, under a general diploid selection model with recurrent parent-independent mutation. Specifically, the method finds the eigenvalues and eigenfunctions of the generator associated with the multi-allelic diffusion, thus yielding an accurate spectral representation of the transition density. Furthermore, this approach allows for efficient, accurate computation of various other quantities of interest, including the normalizing constant of the stationary distribution and the rate of convergence to this distribution.

Full work available at URL: https://arxiv.org/abs/1208.5087

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zbMATH Keywords

spectral decompositionWright-Fisher diffusionmultiple allelespartial differential equationgeneral diploid selectiontransition density function

Mathematics Subject Classification ID

Problems related to evolution (92D15) Population dynamics (general) (92D25) Spectral operators, decomposable operators, well-bounded operators, etc. (47B40) Applications of stochastic analysis (to PDEs, etc.) (60H30)

Cited In (14)

• Diffusion processes satisfying a conservation law constraint
• A stochastic diffusion process for Lochner's generalized Dirichlet distribution
• A coalescent dual process for a Wright-Fisher diffusion with recombination and its application to haplotype partitioning
• On recurrent properties of Fisher-Wright's diffusion on \((0,1)\) with mutation
• A stochastic diffusion process for the Dirichlet distribution
• A simple, semi-deterministic approximation to the distribution of selective sweeps in large populations
• Eigenfunctions and the Dirichlet Problem for the Classical Kimura Diffusion Operator
• The evolution of moment generating functions for the Wright-Fisher model of population genetics
• The common ancestor type distribution of a \(\Lambda\)-Wright-Fisher process with selection and mutation
• On the Simpson index for the Wright-Fisher process with random selection and immigration
• A novel spectral method for inferring general diploid selection from time series genetic data
• Analysis and rejection sampling of Wright-Fisher diffusion bridges
• Bayesian inference of selection in the Wright-Fisher diffusion model
• Inference in population genetics using forward and backward, discrete and continuous time processes

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