A mathematical model for the effects of HER2 over-expression on cell cycle progression in breast cancer

DOI10.1007/S11538-011-9663-3MaRDI QIDQ417285zbMATH OpenOpenAlexWikidataFDO

Authors Amina Eladdadi, David Isaacson

Publication date 14 May 2012

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s11538-011-9663-3

zbMATH Keywords

breast cancercell proliferationmathematical modelingcell cycleEGFRHER2HER2 over-expressionreceptor modeling

Mathematics Subject Classification ID

Medical applications (general) (92C50) Cell biology (92C37)

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Cites work

• A generalised age- and phase-structured model of human tumour cell populations both unperturbed and exposed to a range of cancer therapies
• A history of the study of solid tumour growth: the contribution of mathematical modelling
• A mathematical model for the effects of HER2 overexpression on cell proliferation in breast cancer
• A theoretical analysis of interval drug dosing for cell-cycle-phase- specific drugs
• Analysis of a molecular structured population model with possible polynomial growth for the cell division cycle
• Modelling the flow of cytometric data obtained from unperturbed human tumour cell lines: parameter fitting and comparison
• Necessary and sufficient conditions for asynchronous exponential growth in age structured cell populations with quiescence

Cited in

(7)

• A robust optimal control framework for controlling aberrant RTK signaling pathways in esophageal cancer
• A mathematical model for the effects of HER2 overexpression on cell proliferation in breast cancer
• Mathematical modelling of Her2 (ErbB2) PI3K/AKT signalling pathways during breast carcinogenesis to include PTPD2
• A PINN-driven Fokker-Planck dynamical modeling and control framework for EGFR signaling pathways in esophageal cancer
• A mathematical model of cell cycle progression applied to the MCF-7 breast cancer cell line
• The formation of tight tumor clusters affects the efficacy of cell cycle inhibitors: a hybrid model study
• Mathematics + cancer: an undergraduate ``bridge course in applied mathematics

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