The formation of tight tumor clusters affects the efficacy of cell cycle inhibitors: a hybrid model study

DOI10.1016/J.JTBI.2014.02.027MaRDI QIDQ2632855zbMATHOpenAlexWikidataFDO

Authors Damon Reed, Katarzyna A. Rejniak, Munju Kim

Publication date 15 May 2019

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2014.02.027

zbMATH Keywords

cell motilityagent-based modelCDK inhibitioncell cycle checkpointstumor cluster

Mathematics Subject Classification ID

Medical applications (general) (92C50) Biochemistry, molecular biology (92C40)

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Cites work

• A HYBRID MODEL FOR TUMOR SPHEROID GROWTH IN VITRO I: THEORETICAL DEVELOPMENT AND EARLY RESULTS
• A Multiple Scale Model for Tumor Growth
• A generalised age- and phase-structured model of human tumour cell populations both unperturbed and exposed to a range of cancer therapies
• A hybrid approach to multi-scale modelling of cancer
• A hybrid mathematical model of solid tumour invasion: the importance of cell adhesion
• A hybrid model of tumor-stromal interactions in breast cancer
• A mathematical model for the effects of HER2 over-expression on cell cycle progression in breast cancer
• A mathematical model of cell cycle effects in gastric cancer chemotherapy
• A mathematical model of cell cycle progression applied to the MCF-7 breast cancer cell line
• A multiple time-scale computational model of a tumor and its micro environment
• An agent-based model for elasto-plastic mechanical interactions between cells, basement membrane and extracellular matrix
• An immersed boundary framework for modelling the growth of individual cells: an application to the early tumour development
• Front instabilities and invasiveness of simulated avascular tumors
• Mathematical modeling of monoclonal conversion in the colonic crypt
• Microenvironment driven invasion: a multiscale multimodel investigation
• Modelling the effects of cell-cycle heterogeneity on the response of a solid tumour to chemotherapy: biological insights from a hybrid multiscale cellular automaton model
• Modelling the role of the basement membrane beneath a growing epithelial monolayer
• On aggregation in CA models in biology
• Patient-calibrated agent-based modelling of ductal carcinoma in situ (DCIS): from microscopic measurements to macroscopic predictions of clinical progression
• Tamoxifen treatment failure in cancer and the nonlinear dynamics of TGF\(\beta\)

Cited in

(7)

• Multiscale modelling of palisade formation in gliobastoma multiforme
• Modelling the motion of clusters of cells in a viscous fluid using the boundary integral method
• A simple mathematical model of cell clustering by chemotaxis
• The universal growth rate behavior and regime transition in adherent cell colonies
• Mathematical models of cell clustering due to chemotaxis
• Unraveling the complexity of cell cycle effects of anticancer drugs in cell populations
• A mathematical model of cell movement and clustering due to chemotaxis

Describes a project that uses

Uses Software

• Chaste
• CellAnimation

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