TWO-SAMPLE CONTINUAL REASSESSMENT METHOD

DOI10.1081/BIP-100100998MaRDI QIDQ4244513zbMATH OpenOpenAlexWikidataFDO

Authors John O'Quigley, Larry Zaiqian Shen, A. C. Gamst

Publication date 5 September 1999

Published in Journal of Biopharmaceutical Statistics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1081/bip-100100998

zbMATH Keywords

phase I clinical trialsdose-toxicitypatient heterogeneity

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical design (62L05)

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Cited in

(14)

• Individualized dosing for multiple ordered groups of patients
• Patient-specific dose finding in phase I clinical trials
• Incorporating a patient dichotomous characteristic in cancer phase I clinical trials using escalation with overdose control
• Continual reassessment method for ordered groups
• Dose finding with escalation with overdose control (EWOC) in cancer clinical trials
• Theoretical study of the continual reassessment method
• Bayesian adaptive design of early-phase clinical trials for precision medicine based on cancer biomarkers
• Adaptive clinical trial designs for phase I cancer studies
• Efficiency of bridging between related dose finding studies
• The Continual Reassessment Method for Multiple Toxicity Grades: A Bayesian Quasi‐Likelihood Approach
• Continual reassessment and related dose-finding designs
• Design efficiency in dose finding studies
• A Bayesian adaptive design in cancer phase I trials using dose combinations in the presence of a baseline covariate
• Patient‐Specific Dose Finding Based on Bivariate Outcomes and Covariates

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