Receptor-mediated models for leukocyte chemotaxis
It is well established that leukocytes like polymorphonuclear neutrophils (PMNs) exhibit chemotaxis in a spatial concentration gradient of a chemotactic factor (CF), that is, biased extension of lamellipods in the gradient direction leading to biased ``turning and orientation during locomotion. Two central and inextricably related questions remain unanswered: what are the molecular mechanisms by which a PMN senses and responds to a spatial gradient, albeit imperfectly, and how does the PMN retain the ability to do so over a large range of concentrations as it migrates in a meandering fashion up a gradient? While it is clear that the answers ultimately lie in the emerging details of receptor-mediated messenger generation and consequent modulation of the actin-based motility system of the cell, they will require an integrated understanding of these biochemical and biophysical phenomena. Our goal here is to examine these questions together from the viewpoint of mathematical models which facilitate such integration. For the entire collection see [Zbl 0877.00017].
- Stochastic model of chemoattractant receptor dynamics in leukocyte chemosensory movement
- Hybrid models of chemotaxis with application to leukocyte migration
- Stochastic model of leukocyte chemosensory movement
- Stochastic model of receptor-mediated cytomechanics and dynamic morphology of leukocytes
- Development and applications of a model for cellular response to multiple chemotactic cues
- A model for cell migration in competing chemotactant fields
- Kinetic Models of Chemotaxis
- Model for chemotaxis
- scientific article; zbMATH DE number 5010833
- Stochastic model of leukocyte chemosensory movement
- Stochastic model of chemoattractant receptor dynamics in leukocyte chemosensory movement
- The Role of Receptor Occupancy Noise in Eukaryotic Chemotaxis
- scientific article; zbMATH DE number 1230006 (Why is no real title available?)
- The influence of receptor positioning on chemotactic information
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