Change-point model on nonhomogeneous Poisson processes with application in copy number profiling by next-generation DNA sequencing
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Bayesian inference (62F15) Markov processes: estimation; hidden Markov models (62M05) Applications of statistics to biology and medical sciences; meta analysis (62P10) Parametric tolerance and confidence regions (62F25) Non-Markovian processes: estimation (62M09) Biochemistry, molecular biology (92C40)
Abstract: We propose a flexible change-point model for inhomogeneous Poisson Processes, which arise naturally from next-generation DNA sequencing, and derive score and generalized likelihood statistics for shifts in intensity functions. We construct a modified Bayesian information criterion (mBIC) to guide model selection, and point-wise approximate Bayesian confidence intervals for assessing the confidence in the segmentation. The model is applied to DNA Copy Number profiling with sequencing data and evaluated on simulated spike-in and real data sets.
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Cited in
(15)- Model selection for high dimensional multi-sequence change-point problems
- A Bayesian approach to inference about a change point model with application to DNA copy number experimental data
- A Bayesian approach for locating change points in a compound Poisson process with application to detecting DNA copy number variations
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