Regularization for Cox's proportional hazards model with NP-dimensionality

DOI10.1214/11-AOS911zbMATH Open1246.62202arXiv1010.5233OpenAlexW1989453064WikidataQ29300479 ScholiaQ29300479MaRDI QIDQ449987FDOQ449987

Authors: Jelena Bradic, Jiancheng Jiang, Jianqing Fan 

Publication date: 3 September 2012

Published in: The Annals of Statistics (Search for Journal in Brave)

Abstract: High throughput genetic sequencing arrays with thousands of measurements per sample and a great amount of related censored clinical data have increased demanding need for better measurement specific model selection. In this paper we establish strong oracle properties of nonconcave penalized methods for nonpolynomial (NP) dimensional data with censoring in the framework of Cox's proportional hazards model. A class of folded-concave penalties are employed and both LASSO and SCAD are discussed specifically. We unveil the question under which dimensionality and correlation restrictions can an oracle estimator be constructed and grasped. It is demonstrated that nonconcave penalties lead to significant reduction of the "irrepresentable condition" needed for LASSO model selection consistency. The large deviation result for martingales, bearing interests of its own, is developed for characterizing the strong oracle property. Moreover, the nonconcave regularized estimator, is shown to achieve asymptotically the information bound of the oracle estimator. A coordinate-wise algorithm is developed for finding the grid of solution paths for penalized hazard regression problems, and its performance is evaluated on simulated and gene association study examples.

Full work available at URL: https://arxiv.org/abs/1010.5233

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zbMATH Keywords

SCADlarge deviationsLASSOhazard rateoracle properties

Mathematics Subject Classification ID

Censored data models (62N01) Estimation in survival analysis and censored data (62N02) Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50) Large deviations (60F10) Martingales with continuous parameter (60G44)

Cites Work

• Nearly unbiased variable selection under minimax concave penalty
• A unified approach to model selection and sparse recovery using regularized least squares
• Pathwise coordinate optimization
• Coordinate descent algorithms for lasso penalized regression
• Title not available (Why is that?)
• Variable Selection via Nonconcave Penalized Likelihood and its Oracle Properties
• Title not available (Why is that?)
• Lasso-type recovery of sparse representations for high-dimensional data
• On the conditions used to prove oracle results for the Lasso
• Simultaneous analysis of Lasso and Dantzig selector
• The Dantzig selector: statistical estimation when \(p\) is much larger than \(n\). (With discussions and rejoinder).
• High-dimensional graphs and variable selection with the Lasso
• Title not available (Why is that?)
• Variable selection for Cox's proportional hazards model and frailty model
• Sparsity oracle inequalities for the Lasso
• Regularization for Cox's proportional hazards model with NP-dimensionality
• Title not available (Why is that?)
• The sparsity and bias of the LASSO selection in high-dimensional linear regression
• Cox's regression model for counting processes: A large sample study
• On the Non-Negative Garrotte Estimator
• A general class of exponential inequalities for martingales and ratios
• Smoothly Clipped Absolute Deviation on High Dimensions
• Exponential inequalities for martingales, with application to maximum likelihood estimation for counting processes
• The Dantzig selector and sparsity oracle inequalities
• An iterative thresholding algorithm for linear inverse problems with a sparsity constraint
• Title not available (Why is that?)
• Nonconcave Penalized Likelihood With NP-Dimensionality
• Variable selection for multivariate failure time data
• The Lasso as an \(\ell _{1}\)-ball model selection procedure
• On Lasso for censored data
• Hierarchically penalized Cox regression with grouped variables
• Penalized variable selection procedure for Cox models with semiparametric relative risk

Cited In (79)

• Penalized and Shrinkage Estimation in the Cox Proportional Hazards Model
• Concentration inequalities, counting processes and adaptive statistics
• Simultaneous variable selection and estimation for joint models of longitudinal and failure time data with interval censoring
• False discovery rate control for high-dimensional Cox model with uneven data splitting
• Ensuring valid inference for Cox hazard ratios after variable selection
• Time-varying Hazards Model for Incorporating Irregularly Measured, High-Dimensional Biomarkers
• Variable selection using P-splines
• Binacox: automatic cut‐point detection in high‐dimensional Cox model with applications in genetics
• Efficient estimation of the maximal association between multiple predictors and a survival outcome
• Best subset selection with shrinkage: sparse additive hazards regression with the grouping effect
• Envelopes and principal component regression
• Greedy Variable Selection for High-Dimensional Cox Models
• Variable selection and subgroup analysis for high-dimensional censored data
• Penalized weighted proportional hazards model for robust variable selection and outlier detection
• Improvement screening for ultra-high dimensional data with censored survival outcomes and varying coefficients
• Treatment Effect Estimation Under Additive Hazards Models With High-Dimensional Confounding
• Title not available (Why is that?)
• Analysis of overfitting in the regularized Cox model
• Adaptive bridge estimator for Cox model with a diverging number of parameters
• Subgroup analysis in the heterogeneous Cox model
• CoxKnockoff: controlled feature selection for the Cox model using knockoffs
• Variable selection for high-dimensional partly linear additive Cox model with application to Alzheimer's disease
• Feature screening in ultrahigh-dimensional varying-coefficient Cox model
• Adaptive estimation of the baseline hazard function in the Cox model by model selection, with high-dimensional covariates
• A modified adaptive Lasso for identifying interactions in the Cox model with the heredity constraint
• Scalable estimation and inference for censored quantile regression process
• The variable selection by the Dantzig selector for Cox's proportional hazards model
• Double-slicing assisted sufficient dimension reduction for high-dimensional censored data
• Partially linear structure selection in Cox models with varying coefficients
• Penalized least squares approximation methods and their applications to stochastic processes
• Gene-environment interaction analysis under the Cox model
• Regularized estimation in sparse high-dimensional multivariate regression, with application to a DNA methylation study
• A penalized estimation for the Cox model with ordinal multinomial covariates
• Adaptive kernel estimation of the baseline function in the Cox model with high-dimensional covariates
• Deep learning for the partially linear Cox model
• Inference under Fine-Gray competing risks model with high-dimensional covariates
• Feature selection of ultrahigh-dimensional covariates with survival outcomes: a selective review
• Oracle inequalities for the Lasso in the high-dimensional Aalen multiplicative intensity model
• Scalable proximal methods for cause-specific hazard modeling with time-varying coefficients
• SCAD-penalized regression in additive partially linear proportional hazards models with an ultra-high-dimensional linear part
• High dimensional censored quantile regression
• ESTIMATION FOR THE PREDICTION OF POINT PROCESSES WITH MANY COVARIATES
• The Lasso for High Dimensional Regression with a Possible Change Point
• Estimation by polynomial splines with variable selection in additive Cox models
• Forward regression for Cox models with high-dimensional covariates
• An efficient algorithm for joint feature screening in ultrahigh-dimensional Cox's model
• Variable selection in partially linear additive hazards model with grouped covariates and a diverging number of parameters
• Regularized estimation for highly multivariate log Gaussian Cox processes
• High-dimensional Cox regression analysis in genetic studies with censored survival outcomes
• Penalised empirical likelihood for the additive hazards model with high-dimensional data
• Title not available (Why is that?)
• Feature screening in ultrahigh-dimensional additive Cox model
• Penalized regression for interval-censored times of disease progression: selection of HLA markers in psoriatic arthritis
• Bi-selection in the high-dimensional additive hazards regression model
• On the sign consistency of the Lasso for the high-dimensional Cox model
• The Dantzig Selector for Diffusion Processes with Covariates
• Variable selection in discrete survival models including heterogeneity
• The \(l_q\) consistency of the Dantzig selector for Cox's proportional hazards model
• Structured estimation for the nonparametric Cox model
• Model-free feature screening for high-dimensional survival data
• On an extension of the promotion time cure model
• Simultaneous Estimation and Variable Selection for Interval-Censored Data With Broken Adaptive Ridge Regression
• SICA for Cox's proportional hazards model with a diverging number of parameters
• Variable selection in Cox regression models with varying coefficients
• Variable screening for varying coefficient models with ultrahigh-dimensional survival data
• Shrinkage variable selection and estimation in proportional hazards models with additive structure and high dimensionality
• Variable selection and structure identification for varying coefficient Cox models
• Strong oracle optimality of folded concave penalized estimation
• Joint feature screening for ultra-high-dimensional sparse additive hazards model by the sparsity-restricted pseudo-score estimator
• Regularization for Cox's proportional hazards model with NP-dimensionality
• Confidence intervals for high-dimensional Cox models
• A NEW MULTILEVEL MODELING APPROACH FOR CLUSTERED SURVIVAL DATA
• Title not available (Why is that?)
• A distribution-based Lasso for a general single-index model
• Oracle inequalities for the lasso in the Cox model
• Nonconcave penalized composite conditional likelihood estimation of sparse Ising models
• A sequential feature selection procedure for high-dimensional Cox proportional hazards model
• High-Dimensional Sparse Additive Hazards Regression
• Elastic net for Cox’s proportional hazards model with a solution path algorithm

Uses Software

• glmnet

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