Asymptotic properties of the sequential empirical ROC, PPV and NPV curves under case-control sampling
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Abstract: The receiver operating characteristic (ROC) curve, the positive predictive value (PPV) curve and the negative predictive value (NPV) curve are three measures of performance for a continuous diagnostic biomarker. The ROC, PPV and NPV curves are often estimated empirically to avoid assumptions about the distributional form of the biomarkers. Recently, there has been a push to incorporate group sequential methods into the design of diagnostic biomarker studies. A thorough understanding of the asymptotic properties of the sequential empirical ROC, PPV and NPV curves will provide more flexibility when designing group sequential diagnostic biomarker studies. In this paper, we derive asymptotic theory for the sequential empirical ROC, PPV and NPV curves under case-control sampling using sequential empirical process theory. We show that the sequential empirical ROC, PPV and NPV curves converge to the sum of independent Kiefer processes and show how these results can be used to derive asymptotic results for summaries of the sequential empirical ROC, PPV and NPV curves.
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Cites work
- scientific article; zbMATH DE number 1194782 (Why is no real title available?)
- scientific article; zbMATH DE number 1348603 (Why is no real title available?)
- scientific article; zbMATH DE number 1865745 (Why is no real title available?)
- Asymptotic properties of the sequential empirical ROC, PPV and NPV curves under case-control sampling
- Nonparametric and Semiparametric Group Sequential Methods for Comparing Accuracy of Diagnostic Tests
- Nonparametric and semiparametric estimation of the receiver operating characteristic curve
- Quantifying and comparing the predictive accuracy of continuous prognostic factors for binary outcomes
- Sequential monitoring of response-adaptive randomized clinical trials
- Time-Dependent Predictive Values of Prognostic Biomarkers With Failure Time Outcome
- Unbiased estimation of secondary parameters following a sequential test
- Weak Convergence of a Two-sample Empirical Process and a New Approach to Chernoff-Savage Theorems
Cited in
(5)- Group sequential comparison of positive predictive value curves for correlated biomarker data
- Adaptive trial designs in diagnostic accuracy research
- Sequential estimate of partial area under ROC curve with \(\beta \)-protection and optimal ratio of cases to controls
- Unbiased estimation of biomarker panel performance when combining training and testing data in a group sequential design
- Asymptotic properties of the sequential empirical ROC, PPV and NPV curves under case-control sampling
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