Asymptotic properties of the sequential empirical ROC, PPV and NPV curves under case-control sampling

DOI10.1214/11-AOS937zbMATH Open1246.62213arXiv1203.3014WikidataQ42609222 ScholiaQ42609222MaRDI QIDQ449996FDOQ449996

Authors: Joseph S. Koopmeiners, Ziding Feng 

Publication date: 3 September 2012

Published in: The Annals of Statistics (Search for Journal in Brave)

Abstract: The receiver operating characteristic (ROC) curve, the positive predictive value (PPV) curve and the negative predictive value (NPV) curve are three measures of performance for a continuous diagnostic biomarker. The ROC, PPV and NPV curves are often estimated empirically to avoid assumptions about the distributional form of the biomarkers. Recently, there has been a push to incorporate group sequential methods into the design of diagnostic biomarker studies. A thorough understanding of the asymptotic properties of the sequential empirical ROC, PPV and NPV curves will provide more flexibility when designing group sequential diagnostic biomarker studies. In this paper, we derive asymptotic theory for the sequential empirical ROC, PPV and NPV curves under case-control sampling using sequential empirical process theory. We show that the sequential empirical ROC, PPV and NPV curves converge to the sum of independent Kiefer processes and show how these results can be used to derive asymptotic results for summaries of the sequential empirical ROC, PPV and NPV curves.

Full work available at URL: https://arxiv.org/abs/1203.3014

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zbMATH Keywords

diagnostic testingempirical process theorygroup sequential methods

Mathematics Subject Classification ID

Estimation in survival analysis and censored data (62N02) Applications of statistics to biology and medical sciences; meta analysis (62P10) Nonparametric inference (62G99) Sequential statistical methods (62L99)

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• Asymptotic properties of the sequential empirical ROC, PPV and NPV curves under case-control sampling
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Cited In (5)

• Sequential estimate of partial area under ROC curve with \(\beta \)-protection and optimal ratio of cases to controls
• Asymptotic properties of the sequential empirical ROC, PPV and NPV curves under case-control sampling
• Group sequential comparison of positive predictive value curves for correlated biomarker data
• Adaptive trial designs in diagnostic accuracy research
• Unbiased estimation of biomarker panel performance when combining training and testing data in a group sequential design

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