Pathogen evolution in switching environments: a hybrid dynamical system approach

DOI10.1016/J.MBS.2012.06.004MaRDI QIDQ452473zbMATHOpenAlexWikidataFDO

Authors József Z. Farkas, Peter Hinow, Jan Engelstädter

Publication date 21 September 2012

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1104.3001

zbMATH Keywords

stability in probabilityhybrid switching systempathogen evolution

Mathematics Subject Classification ID

Problems related to evolution (92D15) Physiological, cellular and medical topics (92C99)

Abstract: We propose a hybrid dynamical system approach to model the evolution of a pathogen that experiences different selective pressures according to a stochastic process. In every environment, the evolution of the pathogen is described by a version of the Fisher-Haldane-Wright equation while the switching between environments follows a Markov jump process. We investigate how the qualitative behavior of a simple single-host deterministic system changes when the stochastic switching process is added. In particular, we study the stability in probability of monomorphic equilibria. We prove that in a "constantly" fluctuating environment, the genotype with the highest mean fitness is asymptotically stable in probability. However, if the probability of host switching depends on the genotype composition of the population, polymorphism can be stably maintained. This is a corrected version of the paper that appeared in Mathematical Biosciences 240 (2012), p. 70-75. A corrigendum has appeared in the same journal.

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Cites work

• scientific article; zbMATH DE number 1113626 (Why is no real title available?)
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Cited in

(3)

• Stochastic switching in infinite dimensions with applications to random parabolic PDE
• DYNAMICS OF THE TRANSITION TO PATHOGENICITY INERWINIA CHRYSANTHEMI
• Pathogen evolution when transmission and virulence are stochastic

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