Pathogen evolution in switching environments: a hybrid dynamical system approach

DOI10.1016/J.MBS.2012.06.004zbMATH Open1319.92034arXiv1104.3001OpenAlexW2027750937WikidataQ51348681 ScholiaQ51348681MaRDI QIDQ452473FDOQ452473

Authors: József Z. Farkas, Peter Hinow, Jan Engelstädter 

Publication date: 21 September 2012

Published in: Mathematical Biosciences (Search for Journal in Brave)

Abstract: We propose a hybrid dynamical system approach to model the evolution of a pathogen that experiences different selective pressures according to a stochastic process. In every environment, the evolution of the pathogen is described by a version of the Fisher-Haldane-Wright equation while the switching between environments follows a Markov jump process. We investigate how the qualitative behavior of a simple single-host deterministic system changes when the stochastic switching process is added. In particular, we study the stability in probability of monomorphic equilibria. We prove that in a "constantly" fluctuating environment, the genotype with the highest mean fitness is asymptotically stable in probability. However, if the probability of host switching depends on the genotype composition of the population, polymorphism can be stably maintained. This is a corrected version of the paper that appeared in Mathematical Biosciences 240 (2012), p. 70-75. A corrigendum has appeared in the same journal.

Full work available at URL: https://arxiv.org/abs/1104.3001

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zbMATH Keywords

stability in probabilityhybrid switching systempathogen evolution

Mathematics Subject Classification ID

Problems related to evolution (92D15) Physiological, cellular and medical topics (92C99)

Cites Work

• Hybrid switching diffusions. Properties and applications
• Evolutionary game theory: theoretical concepts and applications to microbial communities
• On competitive Lotka-Volterra model in random environments
• An exact stochastic hybrid model of excitable membranes including spatio-temporal evolution
• Dynamics of games and genes: Discrete versus continuous time
• Title not available (Why is that?)
• Random temporal variation in selection intensities: Case of large population size
• Temporal fluctuations in selection intensities: Case of small population size
• The effects of stochastic environments on allele frequencies in natural populations

Cited In (3)

• Stochastic Switching in Infinite Dimensions with Applications to Random Parabolic PDE
• DYNAMICS OF THE TRANSITION TO PATHOGENICITY INERWINIA CHRYSANTHEMI
• Pathogen evolution when transmission and virulence are stochastic

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