Phenotypic switching of populations of cells in a stochastic environment
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Publication:4964490
DOI10.1088/1742-5468/AAA78EzbMATH Open1459.92061arXiv1706.07789OpenAlexW2685821560MaRDI QIDQ4964490FDOQ4964490
Authors: Peter G. Hufton, Yen Ting Lin, Tobias Galla 
Publication date: 2 March 2021
Published in: Journal of Statistical Mechanics: Theory and Experiment (Search for Journal in Brave)
Abstract: In biology phenotypic switching is a common bet-hedging strategy in the face of uncertain environmental conditions. Existing mathematical models often focus on periodically changing environments to determine the optimal phenotypic response. We focus on the case in which the environment switches randomly between discrete states. Starting from an individual-based model we derive stochastic differential equations to describe the dynamics, and obtain analytical expressions for the mean instantaneous growth rates based on the theory of piecewise deterministic Markov processes. We show that optimal phenotypic responses are non-trivial for slow and intermediate environmental processes, and systematically compare the cases of periodic and random environments. The best response to random switching is more likely to be heterogeneity than in the case of deterministic periodic environments, net growth rates tend to be higher under stochastic environmental dynamics. The combined system of environment and population of cells can be interpreted as host-pathogen interaction, in which the host tries to choose environmental switching so as to minimise growth of the pathogen, and in which the pathogen employs a phenotypic switching optimised to increase its growth rate. We discuss the existence of Nash-like mutual best-response scenarios for such host-pathogen games.
Full work available at URL: https://arxiv.org/abs/1706.07789
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Cited In (21)
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- An age-structured model for coupling within-host and between-host dynamics in environmentally-driven infectious diseases
- Where do mistakes lead? A survey of games with incompetent players
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- The evolution of bet-hedging adaptations to rare scenarios
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