Efficient Computation of Sensitivities for Ordinary Differential Equation Boundary Value Problems
The authors derive adjoint equations for sensivity analysis of models described by boundary value problems for ordinary differential equations. The main goal of the paper is to justify that the adjoint method offers an efficient means of computing sensivities, particularly if there are many parameters. It is also proved that for the considered classes of problems, the adjoint problems are well-posed and inherit the stability of the original system. In this sense, it is shown that numerical stability of the midpoint method for the original system implies numerical stability for the adjoint system. In the last section of the paper the computation of sensivities via the adjoint method is illustrated on a simple example.
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