A discrete in continuous mathematical model of cardiac progenitor cells formation and growth as spheroid clusters (Cardiospheres)

DOI10.1093/IMAMMB/DQW022zbMATH Open1404.92026arXiv1512.07033OpenAlexW3104332853WikidataQ47998347 ScholiaQ47998347MaRDI QIDQ4559629FDOQ4559629

Authors: E. Di Costanzo, Alessandro Giacomello, Elisa Messina, Roberto Natalini, Giuseppe Pontrelli, Fabrizio Rossi, R. G. Smits, Monika Twarogowska 

Publication date: 4 December 2018

Published in: Mathematical Medicine and Biology (Search for Journal in Brave)

Abstract: We propose a discrete in continuous mathematical model describing the in vitro growth process of biophsy-derived mammalian cardiac progenitor cells growing as clusters in the form of spheres (Cardiospheres). The approach is hybrid: discrete at cellular scale and continuous at molecular level. In the present model cells are subject to the self-organizing collective dynamics mechanism and, additionally, they can proliferate and differentiate, also depending on stochastic processes. The two latter processes are triggered and regulated by chemical signals present in the environment. Numerical simulations show the structure and the development of the clustered progenitors and are in a good agreement with the results obtained from in vitro experiments.

Full work available at URL: https://arxiv.org/abs/1512.07033

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zbMATH Keywords

chemotaxiscollective dynamicshybrid modelsstem cellscell movementscellular signallingPoisson stochastic processcardiospheres

Mathematics Subject Classification ID

Developmental biology, pattern formation (92C15) Cell movement (chemotaxis, etc.) (92C17) Cell biology (92C37)

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