A discrete in continuous mathematical model of cardiac progenitor cells formation and growth as spheroid clusters (Cardiospheres)

DOI10.1093/IMAMMB/DQW022MaRDI QIDQ4559629zbMATH OpenOpenAlexWikidataFDO

Authors E. Di Costanzo, Alessandro Giacomello, Elisa Messina, Roberto Natalini, Giuseppe Pontrelli, Fabrizio Rossi, R. G. Smits, Monika Twarogowska

Publication date 4 December 2018

Published in Mathematical Medicine and Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1512.07033

zbMATH Keywords

chemotaxiscollective dynamicshybrid modelsstem cellscell movementscellular signallingPoisson stochastic processcardiospheres

Mathematics Subject Classification ID

Developmental biology, pattern formation (92C15) Cell movement (chemotaxis, etc.) (92C17) Cell biology (92C37)

Abstract: We propose a discrete in continuous mathematical model describing the in vitro growth process of biophsy-derived mammalian cardiac progenitor cells growing as clusters in the form of spheres (Cardiospheres). The approach is hybrid: discrete at cellular scale and continuous at molecular level. In the present model cells are subject to the self-organizing collective dynamics mechanism and, additionally, they can proliferate and differentiate, also depending on stochastic processes. The two latter processes are triggered and regulated by chemical signals present in the environment. Numerical simulations show the structure and the development of the clustered progenitors and are in a good agreement with the results obtained from in vitro experiments.

Recommendations

• A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis
• Modelling cardiac tissue growth and remodelling
• Feedback-control induced pattern formation in cardiac myocytes: a mathematical modeling study
• A 3D mathematical model of coupled stem cell-nutrient dynamics in myocardial regeneration therapy
• Mathematical modelling of the heart: cell to organ
• A novel nonlocal partial differential equation model of endothelial progenitor cell cluster formation during the early stages of vasculogenesis
• Cell-to-cell mathematical modeling of arrhythmia phenomena in the heart
• Evolution of mathematical models of cardiomyocyte electrophysiology
• A new approach to modeling early cardiac morphogenesis during c-looping

Cited in

(8)

• Fractional-order \(PI\) control of first order plants with guaranteed time specifications
• A hybrid model of collective motion of discrete particles under alignment and continuum chemotaxis
• Existence of solutions for hybrid systems of differential equations under exogenous information with discontinuous source term
• Global solutions for a path-dependent hybrid system of differential equations under parabolic signal
• A mathematical study of the influence of hypoxia and acidity on the evolutionary dynamics of cancer
• Microscopic, kinetic and hydrodynamic hybrid models of collective motions with chemotaxis: a numerical study
• Existence of solutions for coupled hybrid systems of differential equations for microscopic dynamics and local concentrations
• On a coupled hybrid system of nonlinear differential equations with a nonlocal concentration

This page was built for publication: A discrete in continuous mathematical model of cardiac progenitor cells formation and growth as spheroid clusters (Cardiospheres)

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q4559629)