Relating cell shape and mechanical stress in a spatially disordered epithelium using a vertex-based model
From MaRDI portal
Publication:4559655
DOI10.1093/IMAMMB/DQX008zbMATH Open1404.92023arXiv1611.04744OpenAlexW3105715916WikidataQ47656420 ScholiaQ47656420MaRDI QIDQ4559655FDOQ4559655
Alexander Nestor-Bergmann, Georgina Goddard, Sarah Woolner, Oliver E. Jensen
Publication date: 4 December 2018
Published in: Mathematical Medicine and Biology: A Journal of the IMA (Search for Journal in Brave)
Abstract: Using a popular vertex-based model to describe a spatially disordered planar epithelial monolayer, we examine the relationship between cell shape and mechanical stress at the cell and tissue level. Deriving expressions for stress tensors starting from an energetic formulation of the model, we show that the principal axes of stress for an individual cell align with the principal axes of shape, and we determine the bulk effective tissue pressure when the monolayer is isotropic at the tissue level. Using simulations for a monolayer that is not under peripheral stress, we fit parameters of the model to experimental data for Xenopus embryonic tissue. The model predicts that mechanical interactions can generate mesoscopic patterns within the monolayer that exhibit long-range correlations in cell shape. The model also suggests that the orientation of mechanical and geometric cues for processes such as cell division are likely to be strongly correlated in real epithelia. Some limitations of the model in capturing geometric features of Xenopus epithelial cells are highlighted.
Full work available at URL: https://arxiv.org/abs/1611.04744
Cited In (9)
- Mechanical cell competition in heterogeneous epithelial tissues
- Minimal cellular automaton model with heterogeneous cell sizes predicts epithelial colony growth
- Force networks, torque balance and Airy stress in the planar vertex model of a confluent epithelium
- Competition between epithelial tissue elasticity and surface tension in cancer morphogenesis
- Relaxation and noise-driven oscillations in a model of mitotic spindle dynamics
- A statistical mechanics approach to describe cell reorientation under stretch
- Approximate Bayesian computation reveals the importance of repeated measurements for parameterising cell-based models of growing tissues
- Cells adapt their shapes with their experienced stiffness: a geometrical approach to differentiation
- Bayesian parameter inference for epithelial mechanics
Recommendations
- A Perturbation Problem Arising from a Mechanical Model for Epithelial Morphogenesis 👍 👎
- On Mechanical Modeling of Dynamic Changes in the Structure and Properties of Adherent Cells 👍 👎
- A model for cellular mechanotransduction and contractility at finite strain 👍 👎
- A free boundary mechanobiological model of epithelial tissues 👍 👎
- A dynamic cellular vertex model of growing epithelial tissues 👍 👎
- A cell-based constitutive model for embryonic epithelia and other planar aggregates of biological cells 👍 👎
- Derivation of continuum models from discrete models of mechanical forces in cell populations 👍 👎
- Force networks, torque balance and Airy stress in the planar vertex model of a confluent epithelium 👍 👎
This page was built for publication: Relating cell shape and mechanical stress in a spatially disordered epithelium using a vertex-based model
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q4559655)
