Weighted False Discovery Rate Control in Large-Scale Multiple Testing
From MaRDI portal
(Redirected from Publication:4559699)
Abstract: The use of weights provides an effective strategy to incorporate prior domain knowledge in large-scale inference. This paper studies weighted multiple testing in a decision-theoretic framework. We develop oracle and data-driven procedures that aim to maximize the expected number of true positives subject to a constraint on the weighted false discovery rate. The asymptotic validity and optimality of the proposed methods are established. The results demonstrate that incorporating informative domain knowledge enhances the interpretability of results and precision of inference. Simulation studies show that the proposed method controls the error rate at the nominal level, and the gain in power over existing methods is substantial in many settings. An application to genome-wide association study is discussed.
Recommendations
- Optimal weighting for false discovery rate control
- Mixed directional false discovery rate control in multiple pairwise comparisons using weighted p-values
- Simultaneous control of all false discovery proportions in large-scale multiple hypothesis testing
- scientific article; zbMATH DE number 720689
- False discovery control with p-value weighting
- Optimal false discovery rate control for large scale multiple testing with auxiliary information
- False discovery rate control with multivariate p-values
- Controlling the false discovery exceedance for heterogeneous tests
Cites work
- scientific article; zbMATH DE number 720689 (Why is no real title available?)
- scientific article; zbMATH DE number 4001209 (Why is no real title available?)
- A Direct Approach to False Discovery Rates
- A new approach to multiple testing of grouped hypotheses
- Capturing the severity of type II errors in high-dimensional multiple testing
- Empirical Bayes Analysis of a Microarray Experiment
- Estimating the Null and the Proportion of Nonnull Effects in Large-Scale Multiple Comparisons
- False Discovery Control for Random Fields
- False Discovery Control in Large-Scale Spatial Multiple Testing
- False Discovery Rates for Spatial Signals
- False discovery control with p-value weighting
- False discovery rate control with groups
- Genome-wide significance levels and weighted hypothesis testing
- Large-scale inference. Empirical Bayes methods for estimation, testing, and prediction
- Multiple Hypotheses Testing with Weights
- On the Optimality of Some Multiple Comparison Procedures
- Operating Characteristics and Extensions of the False Discovery Rate Procedure
- Optimal weighting for false discovery rate control
- Oracle and Adaptive Compound Decision Rules for False Discovery Rate Control
- Power-enhanced multiple decision functions controlling family-wise error and false discovery rates
- Selective inference in complex research
- Simultaneous Testing of Grouped Hypotheses: Finding Needles in Multiple Haystacks
- Simultaneous inference: when should hypothesis testing problems be combined?
- The Optimal Discovery Procedure: A New Approach to Simultaneous Significance Testing
- Unsupervised empirical Bayesian multiple testing with external covariates
Cited in
(26)- Genome-wide significance levels and weighted hypothesis testing
- Null-free false discovery rate control using decoy permutations
- Optimal false discovery rate control for large scale multiple testing with auxiliary information
- False discovery control with p-value weighting
- Detection of Local Differences in Spatial Characteristics Between Two Spatiotemporal Random Fields
- LAWS: A Locally Adaptive Weighting and Screening Approach to Spatial Multiple Testing
- Heteroscedasticity-Adjusted Ranking and Thresholding for Large-Scale Multiple Testing
- Multiple testing approaches for hypotheses in integrative genomics
- Large-scale multiple testing: fundamental limits of false discovery rate control and compound oracle
- An Empirical Bayes Approach to Controlling the False Discovery Exceedance
- Accurate error control in high‐dimensional association testing using conditional false discovery rates
- Signal Classification in Large-Scale Multi-Sequence Integrative Analysis Under the HMM Dependence
- False discovery rate control for lesion-symptom mapping with heterogeneous data via weighted p-values
- Simultaneous control of all false discovery proportions in large-scale multiple hypothesis testing
- Joint mirror procedure: controlling false discovery rate for identifying simultaneous signals
- Knockoffs with side information
- Directional false discovery rate control in large-scale multiple comparisons
- Structure–Adaptive Sequential Testing for Online False Discovery Rate Control
- Two-Component Mixture Model in the Presence of Covariates
- Large-scale multiple testing of composite null hypotheses under heteroskedasticity
- Weighted multiple testing procedure for grouped hypotheses with \(k\)-FWER control
- False Discovery Control in Large-Scale Spatial Multiple Testing
- Invidious comparisons: ranking and selection as compound decisions
- Controlling costs: feature selection on a budget
- A spatially adaptive large-scale multiple-testing procedure
- Covariate-assisted ranking and screening for large-scale two-sample inference
This page was built for publication: Weighted False Discovery Rate Control in Large-Scale Multiple Testing
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q4559699)
