Approximate tail probabilities of the maximum of a chi-square field on multi-dimensional lattice points and their applications to detection of loci interactions

DOI10.1007/S10463-013-0419-8MaRDI QIDQ457282zbMATH OpenOpenAlexFDO

Authors Satoshi Kuriki, Yoshiaki Harushima, Hironori Fujisawa, Nori Kurata

Publication date 26 September 2014

Published in Annals of the Institute of Statistical Mathematics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1012.4921

zbMATH Keywords

epistasismultiple testingBateson-Dobzhansky-Muller modelEuler characteristic heuristicexperimental crossingnonlinear renewal theoryQTL analysisvolume-of-tube method

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Random fields (60G60) Statistics of extreme values; tail inference (62G32) Renewal theory (60K05)

Abstract: Define a chi-square random field on a multi-dimensional lattice points index set with a direct-product covariance structure, and consider the distribution of the maximum of this random field. We provide two approximate formulas for the upper tail probability of the distribution based on nonlinear renewal theory and an integral-geometric approach called the volume-of-tube method. This study is motivated by the detection problem of the interactive loci pairs which play an important role in forming biological species. The joint distribution of scan statistics for detecting the pairs is regarded as the chi-square random field above, and hence the multiplicity-adjusted $p$-value can be calculated by using the proposed approximate formulas. By using these formulas, we examine the data of Mizuta, et al. (2010) who reported a new interactive loci pair of rice inter-subspecies.

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Cites work

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