Boosting joint models for longitudinal and time-to-event data

DOI10.1002/BIMJ.201600158zbMATH Open1379.62088arXiv1609.02686OpenAlexW2963155270WikidataQ36315819 ScholiaQ36315819MaRDI QIDQ4597897FDOQ4597897

Authors: Elisabeth Waldmann, David Taylor-Robinson, Nadja Klein, Thomas Kneib, Tania Pressler, Matthias Schmid, Andreas Mayr 

Publication date: 14 December 2017

Published in: Biometrical Journal (Search for Journal in Brave)

Abstract: Joint Models for longitudinal and time-to-event data have gained a lot of attention in the last few years as they are a helpful technique to approach common a data structure in clinical studies where longitudinal outcomes are recorded alongside event times. Those two processes are often linked and the two outcomes should thus be modeled jointly in order to prevent the potential bias introduced by independent modelling. Commonly, joint models are estimated in likelihood based expectation maximization or Bayesian approaches using frameworks where variable selection is problematic and which do not immediately work for high-dimensional data. In this paper, we propose a boosting algorithm tackling these challenges by being able to simultaneously estimate predictors for joint models and automatically select the most influential variables even in high-dimensional data situations. We analyse the performance of the new algorithm in a simulation study and apply it to the Danish cystic fibrosis registry which collects longitudinal lung function data on patients with cystic fibrosis together with data regarding the onset of pulmonary infections. This is the first approach to combine state-of-the art algorithms from the field of machine-learning with the model class of joint models, providing a fully data-driven mechanism to select variables and predictor effects in a unified framework of boosting joint models.

Full work available at URL: https://arxiv.org/abs/1609.02686

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zbMATH Keywords

variable selectionboostinghigh-dimensional datajoint modelinglongitudinal modelstime-to-event analysis

Mathematics Subject Classification ID

Time series, auto-correlation, regression, etc. in statistics (GARCH) (62M10) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cited In (11)

• An update on statistical boosting in biomedicine
• Gradient boosting for linear mixed models
• Boosting for statistical modelling-A non-technical introduction
• Flexible Bayesian additive joint models with an application to type 1 diabetes research
• Prediction of transplant-free survival in idiopathic pulmonary fibrosis patients using joint models for event times and mixed multivariate longitudinal data
• Flexible link functions in a joint hierarchical Gaussian process model
• Dynamic Predictions and Prospective Accuracy in Joint Models for Longitudinal and Time-to-Event Data
• Boosted multivariate trees for longitudinal data
• BAMLSS: Bayesian Additive Models for Location, Scale, and Shape (and Beyond)
• Spatial joint models through Bayesian structured piecewise additive joint modelling for longitudinal and time-to-event data
• More than one way: exploring the capabilities of different estimation approaches to joint models for longitudinal and time-to-event outcomes

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