Flexible Bayesian additive joint models with an application to type 1 diabetes research

DOI10.1002/BIMJ.201600224MaRDI QIDQ4597903zbMATH OpenOpenAlexWikidataFDO

Authors Meike Köhler, Nikolaus Umlauf, Andreas Beyerlein, Christiane Winkler, Anette-Gabriele Ziegler, Sonja Greven

Publication date 14 December 2017

Published in Biometrical Journal (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1611.01485

zbMATH Keywords

longitudinal dataP-splinestime-to-event databiomarkersanisotropic smoothing

Mathematics Subject Classification ID

Time series, auto-correlation, regression, etc. in statistics (GARCH) (62M10) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: The joint modeling of longitudinal and time-to-event data is an important tool of growing popularity to gain insights into the association between a biomarker and an event process. We develop a general framework of flexible additive joint models that allows the specification of a variety of effects, such as smooth nonlinear, time-varying and random effects, in the longitudinal and survival parts of the models. Our extensions are motivated by the investigation of the relationship between fluctuating disease-specific markers, in this case autoantibodies, and the progression to the autoimmune disease type 1 diabetes. By making use of Bayesian P-splines we are in particular able to capture highly nonlinear subject-specific marker trajectories as well as a time-varying association between the marker and the event process allowing new insights into disease progression. The model is estimated within a Bayesian framework and implemented in the R-package bamlss.

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Cited in

(8)

• bamlss
• Flexible link functions in a joint hierarchical Gaussian process model
• Frailty modeling under a selective sampling protocol: an application to type 1 diabetes related autoantibodies
• BAMLSS: Bayesian Additive Models for Location, Scale, and Shape (and Beyond)
• Spatial joint models through Bayesian structured piecewise additive joint modelling for longitudinal and time-to-event data
• Stable non-linear generalized Bayesian joint models for survival-longitudinal data
• Functional data analysis: an introduction and recent developments
• Automatic search intervals for the smoothing parameter in penalized splines

Describes a project that uses

Uses Software

• R

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