Rational design of antibiotic treatment plans: a treatment strategy for managing evolution and reversing resistance

<a class="pub-badge pub-badge--doi" href="https://doi.org/10.1371/JOURNAL.PONE.0122283" rel="nofollow">DOI 10.1371/JOURNAL.PONE.0122283</a><a class="pub-badge pub-badge--grey" href="https://zbmath.org/1375.92032" rel="nofollow">zbMATH</a><a class="pub-badge pub-badge--grey" href="https://openalex.org/works/W1925318597" rel="nofollow">OpenAlex</a><a class="pub-badge pub-badge--grey" href="https://www.wikidata.org/wiki/Q35623227" rel="nofollow"><img src="https://www.wikidata.org/static/favicon/wikidata.ico" class="pub-badge-icon" alt=""/>Wikidata</a><a class="pub-badge pub-badge--mardi" href="https://portal.mardi4nfdi.de/wiki/Item:Q4599258" rel="nofollow">MaRDI QID Q4599258</a><a class="pub-badge pub-badge--grey" href="https://fdo.portal.mardi4nfdi.de/fdo/Q4599258" rel="nofollow">FDO</a>

Authors Portia Mira, Kristina Crona, Devin C. V. Greene, Juan C. Meza, Bernd Sturmfels, Miriam Barlow

Publication date 18 December 2017

Published in PLOS ONE (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1371/journal.pone.0122283

zbMATH Keywords

correlated probability modelequal probability model

Mathematics Subject Classification ID

Medical applications (general) (92C50) Problems related to evolution (92D15)

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(9)

• Optimization problems involving matrix multiplication with applications in materials science and biology
• Bioaugmentation approaches for suppression of antibiotic resistance: model-based design
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• Rotating antibiotics selects optimally against antibiotic resistance, in theory
• Antibiotics time machines are hard to build
• A stochastic programming approach to the antibiotics time machine problem
• The geometry of partial fitness orders and an efficient method for detecting genetic interactions

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