Semiparametric Dose Finding Methods

DOI10.1111/RSSB.12229OpenAlexW2527932218MaRDI QIDQ4603795FDOQ4603795

Authors: Matthieu Clertant, John O'Quigley 

Publication date: 19 February 2018

Published in: Journal of the Royal Statistical Society Series B: Statistical Methodology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/rssb.12229

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zbMATH Keywords

clinical trialscontinual reassessment methodhierarchical modelsadaptive designssequential designsdose finding methodology

Mathematics Subject Classification ID

Nonparametric regression and quantile regression (62G08) Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical design (62L05)

Cited In (11)

• On optimal designs for clinical trials: an updated review
• Statistical frameworks for oncology dose-finding designs with late-onset toxicities: a review
• Dose Finding – A Challenge in Statistics
• A continual reassessment method without undue risk of toxicity
• Comparative review of novel model-assisted designs for phase I/II clinical trials
• A nonparametric Bayesian method for dose finding in drug combinations cancer trials
• Improving the performance of Bayesian logistic regression model with overdose control in oncology dose-finding studies
• Semiparametric Dose Finding Methods for Partially Ordered Drug Combinations
• A system for determining maximum tolerated dose in clinical trial
• The role of minimal sets in dose finding studies
• Evaluation of early phase dose finding algorithms in heterogeneous populations

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