Dynamics of relaxation to a stationary state for interacting molecular motors

DOI10.1088/1751-8121/AA9675zbMATH Open1381.82024arXiv1708.00881OpenAlexW2742194903MaRDI QIDQ4606152FDOQ4606152

Anatoly B. Kolomeisky, Luiza V. F. Gomes

Publication date: 1 March 2018

Published in: Journal of Physics A: Mathematical and Theoretical (Search for Journal in Brave)

Abstract: Motor proteins are active enzymatic molecules that drive a variety of biological processes, including transfer of genetic information, cellular transport, cell motility and muscles contraction. It is known that these biological molecular motors usually perform their cellular tasks by acting collectively, and there are interactions between individual motors that specify the overall collective behavior. One of the fundamental issues related to the collective dynamics of motor proteins is the question if they function at stationary-state conditions. To investigate this problem, we analyze a relaxation to the stationary state for the system of interacting molecular motors. Our approach utilizes a recently developed theoretical framework, which views the collective dynamics of motor proteins as a totally asymmetric simple exclusion process of interacting particles, where interactions are taken into account via a thermodynamically consistent approach. The dynamics of relaxation to the stationary state is analyzed using a domain-wall method that relies on a mean-field description, which takes into account some correlations. It is found that the system quickly relaxes for repulsive interactions, while attractive interactions always slow down reaching the stationary state. It is also predicted that for some range of parameters the fastest relaxation might be achieved for a weak repulsive interaction. Our theoretical predictions are tested with Monte Carlo computer simulations. The implications of our findings for biological systems are briefly discussed.

Full work available at URL: https://arxiv.org/abs/1708.00881

zbMATH Keywords

molecular motorsmotor proteinsasymmetric simple exclusion processesdomain wall approach

Mathematics Subject Classification ID

Statistical mechanics of solids (82D20) Cell biology (92C37)

Cites Work

• Phase diagram of one-dimensional driven lattice gases with open boundaries
• Exact solution of a 1D asymmetric exclusion model using a matrix formulation
• Theoretical analysis of dynamic processes for interacting molecular motors

Cited In (4)

• The effect of local dissociation on dynamics of interacting molecular motors
• The role of dynamic defects in transport of interacting molecular motors
• THE MEAN VELOCITY OF TWO-STATE MODELS OF MOLECULAR MOTOR
• Exclusion process on an open lattice with fluctuating boundaries

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