THE MEAN VELOCITY OF TWO-STATE MODELS OF MOLECULAR MOTOR

DOI10.1142/S0217984911026978zbMATH Open1272.82030arXiv1007.1745MaRDI QIDQ4910591FDOQ4910591

Authors: Yunxin Zhang 

Publication date: 19 March 2013

Published in: Modern Physics Letters B (Search for Journal in Brave)

Abstract: The motion of molecular motor is essential to the biophysical functioning of living cells. In principle, this motion can be regraded as a multiple chemical states process. In which, the molecular motor can jump between different chemical states, and in each chemical state, the motor moves forward or backward in a corresponding potential. So, mathematically, the motion of molecular motor can be described by several coupled one-dimensional hopping models or by several coupled Fokker-Planck equations. To know the basic properties of molecular motor, in this paper, we will give detailed analysis about the simplest cases: in which there are only two chemical states. Actually, many of the existing models, such as the flashing ratchet model, can be regarded as a two-state model. From the explicit expression of the mean velocity, we find that the mean velocity of molecular motor might be nonzero even if the potential in each state is periodic, which means that there is no energy input to the molecular motor in each of the two states. At the same time, the mean velocity might be zero even if there is energy input to the molecular motor. Generally, the velocity of molecular motor depends not only on the potentials (or corresponding forward and backward transition rates) in the two states, but also on the transition rates between the two chemical states.

Full work available at URL: https://arxiv.org/abs/1007.1745

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zbMATH Keywords

Fokker-Planck equationmolecular motortwo-state modelhopping model

Mathematics Subject Classification ID

Stochastic methods (Fokker-Planck, Langevin, etc.) applied to problems in time-dependent statistical mechanics (82C31) Biophysics (92C05)

Cites Work

• Derivation of diffusion coefficient of a Brownian particle in tilted periodic potential from the coordinate moments
• Brownian motors: noisy transport far from equilibrium
• A simplified ``ratchet model of molecular motors
• Mean first-passage and residence times of random walks on asymmetric disordered chains
• The efficiency of molecular motors
• Molecular motor cycles: From ratchets to networks
• LOCAL NATURE OF COSET MODELS

Cited In (3)

• Motor potential profile and a robust method for extracting it from time series of motor positions
• Directed Motion of a Molecular Motor Based on the Four-State Model with Unequal Substeps
• Markov modeling of run length and velocity for molecular motors

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