Mutual Information in Frequency and Its Application to Measure Cross-Frequency Coupling in Epilepsy
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Publication:4622189
DOI10.1109/TSP.2018.2821627zbMATH Open1415.94180arXiv1711.01629MaRDI QIDQ4622189FDOQ4622189
Authors: Rakesh Malladi, Don H. Johnson, Giridhar P. Kalamangalam, Nitin Tandon, Behnaam Aazhang 
Publication date: 12 February 2019
Published in: IEEE Transactions on Signal Processing (Search for Journal in Brave)
Abstract: We define a metric, mutual information in frequency (MI-in-frequency), to detect and quantify the statistical dependence between different frequency components in the data, referred to as cross-frequency coupling and apply it to electrophysiological recordings from the brain to infer cross-frequency coupling. The current metrics used to quantify the cross-frequency coupling in neuroscience cannot detect if two frequency components in non-Gaussian brain recordings are statistically independent or not. Our MI-in-frequency metric, based on Shannon's mutual information between the Cramer's representation of stochastic processes, overcomes this shortcoming and can detect statistical dependence in frequency between non-Gaussian signals. We then describe two data-driven estimators of MI-in-frequency: one based on kernel density estimation and the other based on the nearest neighbor algorithm and validate their performance on simulated data. We then use MI-in-frequency to estimate mutual information between two data streams that are dependent across time, without making any parametric model assumptions. Finally, we use the MI-in- frequency metric to investigate the cross-frequency coupling in seizure onset zone from electrocorticographic recordings during seizures. The inferred cross-frequency coupling characteristics are essential to optimize the spatial and spectral parameters of electrical stimulation based treatments of epilepsy.
Full work available at URL: https://arxiv.org/abs/1711.01629
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