A strongly degenerate diffusion-haptotaxis model of tumour invasion under the go-or-grow dichotomy hypothesis
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cancer cell invasiondegenerate diffusionglobal existencego-or-grow dichotomyhaptotaxisparabolic systemweak solution
A priori estimates in context of PDEs (35B45) Weak solutions to PDEs (35D30) Reaction-diffusion equations (35K57) Degenerate parabolic equations (35K65) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Finite volume methods for initial value and initial-boundary value problems involving PDEs (65M08) Cell movement (chemotaxis, etc.) (92C17)
Abstract: We propose and study a strongly coupled PDE-ODE-ODE system modeling cancer cell invasion through a tissue network under the go-or-grow hypothesis asserting that cancer cells can either move or proliferate. Hence our setting features two interacting cell populations with their mutual transitions and involves tissue-dependent degenerate diffusion and haptotaxis for the moving subpopulation. The proliferating cells and the tissue evolution are characterized by way of ODEs for the respective densities. We prove the global existence of weak solutions and illustrate the model behaviour by numerical simulations in a two-dimensional setting.
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