Uniformly most powerful tests for simultaneously detecting a treatment effect in the overall population and at least one subpopulation

DOI10.1016/J.JSPI.2014.07.001MaRDI QIDQ466533zbMATH OpenOpenAlexWikidataFDO

Authors Michael Rosenblum

Publication date 27 October 2014

Published in Journal of Statistical Planning and Inference (Search for Journal in Brave)

Full work available at URL https://biostats.bepress.com/jhubiostat/paper236

zbMATH Keywords

optimizationpersonalized medicinefamilywise type I error

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Paired and multiple comparisons; multiple testing (62J15)

Recommendations

• Optimal tests of treatment effects for the overall population and two subpopulations in randomized trials, using sparse linear programming
• A multiple comparison procedure for dose-finding trials with subpopulations
• Optimizing randomized trial designs to distinguish which subpopulations benefit from treatment
• An omnibus test for detection of subgroup treatment effects via data partitioning
• Tests for statistical significance of a treatment effect in the presence of hidden sub-populations

Cites work

• scientific article; zbMATH DE number 50804 (Why is no real title available?)
• scientific article; zbMATH DE number 3624650 (Why is no real title available?)
• Asymptotic Statistics
• Bonferroni procedures for logically related hypotheses.
• Exact and Approximate Stepdown Methods for Multiple Hypothesis Testing
• Multiple test procedures for arbitrary dependence structures
• On closed testing procedures with special reference to ordered analysis of variance
• On the rate of convergence in the multivariate CLT
• Optimal testing of multiple hypotheses with common effect direction
• Optimal tests of treatment effects for the overall population and two subpopulations in randomized trials, using sparse linear programming
• Shortcuts for locally consonant closed test procedures
• Simultaneous Test Procedures--Some Theory of Multiple Comparisons
• Testing Statistical Hypotheses
• Testing hypotheses in order
• The partitioning principle: a powerful tool in multiple decision theory

Cited in

(5)

• An omnibus test for detection of subgroup treatment effects via data partitioning
• Optimal tests of treatment effects for the overall population and two subpopulations in randomized trials, using sparse linear programming
• A multiple comparison procedure for dose-finding trials with subpopulations
• Optimal Multiple Testing and Design in Clinical Trials
• Tests for statistical significance of a treatment effect in the presence of hidden sub-populations

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