Uniformly most powerful tests for simultaneously detecting a treatment effect in the overall population and at least one subpopulation

DOI10.1016/J.JSPI.2014.07.001zbMATH Open1307.62188OpenAlexW2095575790WikidataQ37261716 ScholiaQ37261716MaRDI QIDQ466533FDOQ466533

Authors: Michael Rosenblum 

Publication date: 27 October 2014

Published in: Journal of Statistical Planning and Inference (Search for Journal in Brave)

Full work available at URL: https://biostats.bepress.com/jhubiostat/paper236

Recommendations

• Optimal tests of treatment effects for the overall population and two subpopulations in randomized trials, using sparse linear programming
• A multiple comparison procedure for dose-finding trials with subpopulations
• Optimizing randomized trial designs to distinguish which subpopulations benefit from treatment
• An omnibus test for detection of subgroup treatment effects via data partitioning
• Tests for statistical significance of a treatment effect in the presence of hidden sub-populations

zbMATH Keywords

optimizationpersonalized medicinefamilywise type I error

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Paired and multiple comparisons; multiple testing (62J15)

Cites Work

• Asymptotic Statistics
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• Testing Statistical Hypotheses
• On closed testing procedures with special reference to ordered analysis of variance
• Shortcuts for Locally Consonant Closed Test Procedures
• Simultaneous Test Procedures--Some Theory of Multiple Comparisons
• Testing hypotheses in order
• Exact and Approximate Stepdown Methods for Multiple Hypothesis Testing
• Title not available (Why is that?)
• On the rate of convergence in the multivariate CLT
• The partitioning principle: a powerful tool in multiple decision theory
• Multiple test procedures for arbitrary dependence structures
• Bonferroni procedures for logically related hypotheses.
• Optimal testing of multiple hypotheses with common effect direction
• Optimal Tests of Treatment Effects for the Overall Population and Two Subpopulations in Randomized Trials, Using Sparse Linear Programming

Cited In (2)

• Optimal Multiple Testing and Design in Clinical Trials
• An omnibus test for detection of subgroup treatment effects via data partitioning

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