Virus antibody dynamics in primary and secondary dengue infections

DOI10.1007/S00285-013-0749-4zbMATH Open1330.37075arXiv1202.0117OpenAlexW2044620872WikidataQ40222559 ScholiaQ40222559MaRDI QIDQ476827FDOQ476827

Authors: Tanvi P. Gujarati, G. Ambika 

Publication date: 2 December 2014

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Abstract: Dengue viral infections show unique infection patterns arising from its four serot- ypes, (DENV-1,2,3,4). Its effects range from simple fever in primary infections to potentially fatal secondary infections. We analytically and numerically analyse virus dynamics and humoral response in a host during primary and secondary dengue infection for long periods using micro-epidemic models. The models presented here incorporate time delays, antibody dependent enhancement (ADE), a dynamic switch and a correlation factor between different DENV serotypes. We find that the viral load goes down to undetectable levels within 7-14 days as is observed for dengue infection, in both cases. For primary infection, the stability analysis of steady states shows interesting dependence on the time delay involved in the production of antibodies from plasma cells. We demonstrate the existence of a critical value for the immune response parameter, beyond which the infection gets completely cured. For secondary infections with a different serotype, the homologous antibody production is enhanced due to the influence of heterologous antibodies. The antibody production is also controlled by the correlation factor, which is a measure of similarities between the different DENV serotypes involved. Our results agree with clinically observed humoral responses for primary and secondary infections.

Full work available at URL: https://arxiv.org/abs/1202.0117

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zbMATH Keywords

stability analysistime delayantibody dependent enhancementcorrelation factor among serotypeshumoral immune response

Mathematics Subject Classification ID

Medical epidemiology (92C60) Dynamical systems in biology (37N25) Nonlinear ordinary differential equations and systems (34A34) General biology and biomathematics (92B05)

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• A generalized within-host model of dengue infection with a non-constant monocyte production rate
• Simulation model for dynamics of dengue with innate and humoral immune responses
• Dynamical analysis of secondary dengue viral infection with multiple target cells and diffusion by mathematical model
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