Separation of the largest eigenvalues in eigenanalysis of genotype data from discrete subpopulations

DOI10.1016/J.TPB.2013.08.004MaRDI QIDQ481664zbMATH OpenOpenAlexWikidataFDO

Authors Katarzyna Bryc, Jack W. Silverstein, Włodek Bryc

Publication date 12 December 2014

Published in Theoretical Population Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1301.4511, http://europepmc.org/articles/pmc3825268

zbMATH Keywords

eigenanalysiseigenvaluesprincipal components analysispopulation structurenumber of subpopulations

Mathematics Subject Classification ID

Factor analysis and principal components; correspondence analysis (62H25) Applications of statistics to biology and medical sciences; meta analysis (62P10) Genetics and epigenetics (92D10)

Abstract: We present a mathematical model, and the corresponding mathematical analysis, that justifies and quantifies the use of principal component analysis of biallelic genetic marker data for a set of individuals to detect the number of subpopulations represented in the data. We indicate that the power of the technique relies more on the number of individuals genotyped than on the number of markers.

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Cites work

• scientific article; zbMATH DE number 635657 (Why is no real title available?)
• Diffusion models in population genetics
• Edge universality of correlation matrices
• Eigen-Inference for Energy Estimation of Multiple Sources
• On the limit of the largest eigenvalue of the large dimensional sample covariance matrix
• The eigenvalues and eigenvectors of finite, low rank perturbations of large random matrices
• The site-frequency spectrum of linked sites
• The spectral radii and norms of large dimensional non-central random atrices matrices

Cited in

(4)

• Eigenvalue significance testing for genetic association
• Singular values of large non-central random matrices
• Eigenanalysis of SNP data with an identity by descent interpretation
• An Eigenvalue Ratio Approach to Inferring Population Structure from Whole Genome Sequencing Data

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