One-dimensional birth-death process and Delbrück-Gillespie theory of mesoscopic nonlinear chemical reactions

DOI10.1111/J.1467-9590.2012.00567.XMaRDI QIDQ4906050zbMATH OpenOpenAlexFDO

Authors Yunxin Zhang, Hao Ge, Hong Qian

Publication date 21 February 2013

Published in Studies in Applied Mathematics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1207.4214

Mathematics Subject Classification ID

Population dynamics (general) (92D25) Reaction-diffusion equations (35K57) PDEs in connection with biology, chemistry and other natural sciences (35Q92)

Abstract: As a mathematical theory for the stochasstic, nonlinear dynamics of individuals within a population, Delbr"{u}ck-Gillespie process (DGP) $n(t)inmathbb{Z}^N$, is a birth-death system with state-dependent rates which contain the system size $V$ as a natural parameter. For large $V$, it is intimately related to an autonomous, nonlinear ordinary differential equation as well as a diffusion process. For nonlinear dynamical systems with multiple attractors, the quasi-stationary and stationary behavior of such a birth-death process can be underestood in terms of a separation of time scales by a $T^{\ast }sim{e}^{alphaV}$ $(alpha>0)$: a relatively fast, intra-basin diffusion for $tll{T}^{\ast }$ and a much slower inter-basin Markov jump process for $tgg{T}^{\ast }$. In the present paper for one-dimensional systems, we study both stationary behavior ($t=infty$) in terms of invariant distribution $p_n^{ss}(V)$, and finite time dynamics in terms of the mean first passsage time (MFPT) $T_{n_{1}ightarrow{n}_2}(V)$. We obtain an asymptotic expression of MFPT in terms of the "stochastic potential" $Phi(x,V)=-(1/V)ln{p}_{xV}^{ss}(V)$. We show in general no continuous diffusion process can provide asymptotically accurate representations for both the MFPT and the $p_n^{ss}(V)$ for a DGP. When $n_1$ and $n_2$ belong to two different basins of attraction, the MFPT yields the $T^{\ast }(V)$ in terms of $Phi(x,V)approxph{i}_0(x)+(1/V)ph{i}_1(x)$. For systems with a saddle-node bifurcation and catastrophe, discontinuous "phase transition" emerges, which can be characterized by $Phi(x,V)$ in the limit of $Vightarrowinfty$. In terms of time scale separation, the relation between deterministic, local nonlinear bifurcations and stochastic global phase transition is discussed. The one-dimensional theory is a pedagogic first step toward a general theory of DGP.

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