One‐Dimensional Birth‐Death Process and Delbrück‐Gillespie Theory of Mesoscopic Nonlinear Chemical Reactions

DOI10.1111/J.1467-9590.2012.00567.XzbMATH Open1279.35089arXiv1207.4214OpenAlexW1546250069MaRDI QIDQ4906050FDOQ4906050

Publication date: 21 February 2013

Published in: Studies in Applied Mathematics (Search for Journal in Brave)

Abstract: As a mathematical theory for the stochasstic, nonlinear dynamics of individuals within a population, Delbr"{u}ck-Gillespie process (DGP)

n (t) i n m a t h b b Z^{N}

, is a birth-death system with state-dependent rates which contain the system size

V

as a natural parameter. For large

V

, it is intimately related to an autonomous, nonlinear ordinary differential equation as well as a diffusion process. For nonlinear dynamical systems with multiple attractors, the quasi-stationary and stationary behavior of such a birth-death process can be underestood in terms of a separation of time scales by a

T^{*} s i m e^{a l p h a V}

(a l p h a > 0)

: a relatively fast, intra-basin diffusion for

t l l T^{*}

and a much slower inter-basin Markov jump process for

t g g T^{*}

. In the present paper for one-dimensional systems, we study both stationary behavior (

t = i n f t y

) in terms of invariant distribution

p_{n}^{s s} (V)

, and finite time dynamics in terms of the mean first passsage time (MFPT)

T_{n_{1} i g h t a r r o w n_{2}} (V)

. We obtain an asymptotic expression of MFPT in terms of the "stochastic potential"

P h i (x, V) = - (1 / V) l n p_{x V}^{s s} (V)

. We show in general no continuous diffusion process can provide asymptotically accurate representations for both the MFPT and the

p_{n}^{s s} (V)

for a DGP. When

n_{1}

and

n_{2}

belong to two different basins of attraction, the MFPT yields the

T^{*} (V)

in terms of

P h i (x, V) a p p r o x p h i_{0} (x) + (1 / V) p h i_{1} (x)

. For systems with a saddle-node bifurcation and catastrophe, discontinuous "phase transition" emerges, which can be characterized by

P h i (x, V)

in the limit of

V i g h t a r r o w i n f t y

. In terms of time scale separation, the relation between deterministic, local nonlinear bifurcations and stochastic global phase transition is discussed. The one-dimensional theory is a pedagogic first step toward a general theory of DGP.

Full work available at URL: https://arxiv.org/abs/1207.4214

Mathematics Subject Classification ID

Population dynamics (general) (92D25) Reaction-diffusion equations (35K57) PDEs in connection with biology, chemistry and other natural sciences (35Q92)

Cites Work

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