Incubation periods under various anti-retroviral therapies in homogeneous mixing and age-structured dynamical models: a theoretical approach

DOI10.1216/RMJ-2015-45-3-973zbMATH Open1350.92027arXivq-bio/0608028OpenAlexW1854721609MaRDI QIDQ491367FDOQ491367

Authors: Arni S. R. Srinivasa Rao 

Publication date: 25 August 2015

Published in: Rocky Mountain Journal of Mathematics (Search for Journal in Brave)

Abstract: With the launch of second line anti-retroviral therapy for HIV infected individuals, there has been an increased expectation on surviving period of people with HIV. We consider previously well-known models in HIV epidemiology where the parameter for incubation period is used as one of the important components to explain the dynamics of the variables. Such models are extended here to explain the dynamics with respect to a given therapy that prolongs life of an HIV infected individual. A deconvolution method is demonstrated for estimation of parameters in the situations when no-therapy and multiple therapies are given to the infected population. The models and deconvolution method are extended in order to study the impact of therapy in age-structured populations. A generalization for a situation when n-types of therapies are available is given. Models are demonstrated using hypothetical data and sensitivity of the parameters are also computed.

Full work available at URL: https://arxiv.org/abs/q-bio/0608028

Recommendations

• Mathematical Analysis of Age‐Structured HIV‐1 Dynamics with Combination Antiretroviral Therapy
• Mathematical Models and the Design of Public Health Policy: Hiv and Antiviral Therapy
• scientific article; zbMATH DE number 2242529
• A schematic age-structured compartment model of the impact of antiretroviral therapy on HIV incidence and prevalence
• An HIV model with initiating antiretroviral therapy

zbMATH Keywords

deconvolutionepidemic modelsconditional probabilitysecond line ART

Mathematics Subject Classification ID

Medical applications (general) (92C50) Medical epidemiology (92C60) Convolution as an integral transform (44A35)

Cites Work

• Title not available (Why is that?)
• Emergence of HIV-1 drug resistance during antiretroviral treatment
• Mathematical Analysis of HIV-1 Dynamics in Vivo
• Title not available (Why is that?)
• On the role of long incubation periods in the dynamics of acquired immunodeficiency syndrome (AIDS). I: Single population models
• Mathematical Analysis of Age‐Structured HIV‐1 Dynamics with Combination Antiretroviral Therapy
• Possible demographic consequences of HIV/AIDS epidemics. I. Assuming HIV infection always leads to AIDS
• A Method for Obtaining Short-Term Projections and Lower Bounds on the Size of the AIDS Epidemic
• A modulated time-varying density function for the incubation period of AIDS
• An age-structured model for the AIDS epidemic
• Incubation-time distribution in back-calculation applied to HIV/AIDS data in India
• Parametric models for incubation distribution in presence of left and right censoring.
• A combination of differential equations and convolution in understanding the spread of an epidemic
• HIV/AIDS epidemic in India and predicting the impact of the national response: mathematical modeling and analysis
• Improvement in survival of people living with HIV/AIDS and requirement for 1st- and 2nd-line ART in India: a mathematical model
• Title not available (Why is that?)
• The Epidemiology of HIV Infection: Variable Incubation Plus Infectious Periods and Heterogeneity in Sexual Activity

Cited In (1)

• Generalization of Carey's equality and a theorem on stationary population

This page was built for publication: Incubation periods under various anti-retroviral therapies in homogeneous mixing and age-structured dynamical models: a theoretical approach

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q491367)