Incubation periods under various anti-retroviral therapies in homogeneous mixing and age-structured dynamical models: a theoretical approach

DOI10.1216/RMJ-2015-45-3-973MaRDI QIDQ491367zbMATH OpenOpenAlexFDO

Authors Arni S. R. Srinivasa Rao

Publication date 25 August 2015

Published in Rocky Mountain Journal of Mathematics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/q-bio/0608028, https://projecteuclid.org/euclid.rmjm/1440168299

zbMATH Keywords

deconvolutionepidemic modelsconditional probabilitysecond line ART

Mathematics Subject Classification ID

Medical applications (general) (92C50) Medical epidemiology (92C60) Convolution as an integral transform (44A35)

Abstract: With the launch of second line anti-retroviral therapy for HIV infected individuals, there has been an increased expectation on surviving period of people with HIV. We consider previously well-known models in HIV epidemiology where the parameter for incubation period is used as one of the important components to explain the dynamics of the variables. Such models are extended here to explain the dynamics with respect to a given therapy that prolongs life of an HIV infected individual. A deconvolution method is demonstrated for estimation of parameters in the situations when no-therapy and multiple therapies are given to the infected population. The models and deconvolution method are extended in order to study the impact of therapy in age-structured populations. A generalization for a situation when n-types of therapies are available is given. Models are demonstrated using hypothetical data and sensitivity of the parameters are also computed.

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Cited in

(1)

• Generalization of Carey's equality and a theorem on stationary population

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