Multiple comparisons in complex clinical trial designs

DOI10.1002/BIMJ.201200048MaRDI QIDQ4921957zbMATH OpenOpenAlexWikidataFDO

Authors H. M. James Hung, Sue-Jane Wang

Publication date 28 May 2013

Published in Biometrical Journal (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/bimj.201200048

zbMATH Keywords

group sequentialinterim analysisreplicationstrong controlstrength of evidenceevidence-settingexperiment-wisestudy-wise

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical design (62L05) Paired and multiple comparisons; multiple testing (62J15)

Recommendations

• Challenges to multiple testing in clinical trials
• Panel forum on multiple comparison procedures: A commentary from a complex trial design and analysis plan
• Multiple analyses in clinical trials. Fundamentals for investigators
• Multiple endpoints
• scientific article; zbMATH DE number 1332897

Cites work

• A Multiple Comparison Procedure for Comparing Several Treatments with a Control
• A sharper Bonferroni procedure for multiple tests of significance
• Challenges to multiple testing in clinical trials
• Discrete Sequential Boundaries for Clinical Trials
• Graphical approaches for multiple comparison procedures using weighted Bonferroni, Simes, or parametric tests
• Impacts on type I error rate with inappropriate use of learn and confirm in confirmatory adaptive design trials
• Testing Whether an Identified Treatment Is Best
• Testing a Primary and a Secondary Endpoint in a Group Sequential Design
• Testing for efficacy in primary and secondary endpoints by partitioning decision paths

Cited in

(7)

• Multiple endpoints
• Industry, Government, and Academic Panel Discussion on Multiple Comparisons in a “Real” Phase Three Clinical Trial
• Panel forum on multiple comparison procedures: A commentary from a complex trial design and analysis plan
• Challenges to multiple testing in clinical trials
• Multiple analyses in clinical trials. Fundamentals for investigators
• Optimal Multiple Testing and Design in Clinical Trials
• A Decision Rule for Evaluating Several Independent Clinical Trials Collectively

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