Bayesian model selection in complex linear systems, as illustrated in genetic association studies
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Publication:4979229
DOI10.1111/BIOM.12112zbMATH Open1419.62474arXiv1309.0837OpenAlexW2950305086WikidataQ38273854 ScholiaQ38273854MaRDI QIDQ4979229FDOQ4979229
Authors: Xiaoquan Wen 
Publication date: 17 June 2014
Published in: Biometrics (Search for Journal in Brave)
Abstract: Motivated by examples from genetic association studies, this paper considers the model selection problem in a general complex linear model system and in a Bayesian framework. We discuss formulating model selection problems and incorporating context-dependent {it a priori} information through different levels of prior specifications. We also derive analytic Bayes factors and their approximations to facilitate model selection and discuss their theoretical and computational properties. We demonstrate our Bayesian approach based on an implemented Markov Chain Monte Carlo (MCMC) algorithm in simulations and a real data application of mapping tissue-specific eQTLs. Our novel results on Bayes factors provide a general framework to perform efficient model comparisons in complex linear model systems.
Full work available at URL: https://arxiv.org/abs/1309.0837
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Bayesian inference (62F15) Linear regression; mixed models (62J05) Applications of statistics to biology and medical sciences; meta analysis (62P10)
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Cited In (10)
- A Bayesian group selection with compositional responses for analysis of radiologic tumor proportions and their genomic determinants
- Towards a Bayesian decision theoretic analysis of contextual effect modifiers
- Variable prioritization in nonlinear black box methods: a genetic association case study
- Bayesian polynomial regression models to fit multiple genetic models for quantitative traits
- A Bayesian nonparametric method for model evaluation: application to genetic studies
- Bayesian model search and multilevel inference for SNP association studies
- Variable selection in Bayesian generalized linear‐mixed models: An illustration using candidate gene case‐control association studies
- Joint genome-wide prediction in several populations accounting for randomness of genotypes: a hierarchical Bayes approach. II: Multivariate spike and slab priors for marker effects and derivation of approximate Bayes and fractional Bayes factors for the complete family of models
- A Bayesian algorithm for functional mapping of dynamic complex traits
- Modeling complex phenotypes: generalized linear models using spectrogram predictors of animal communication signals
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