Bayesian model selection in complex linear systems, as illustrated in genetic association studies
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Publication:4979229
Abstract: Motivated by examples from genetic association studies, this paper considers the model selection problem in a general complex linear model system and in a Bayesian framework. We discuss formulating model selection problems and incorporating context-dependent {it a priori} information through different levels of prior specifications. We also derive analytic Bayes factors and their approximations to facilitate model selection and discuss their theoretical and computational properties. We demonstrate our Bayesian approach based on an implemented Markov Chain Monte Carlo (MCMC) algorithm in simulations and a real data application of mapping tissue-specific eQTLs. Our novel results on Bayes factors provide a general framework to perform efficient model comparisons in complex linear model systems.
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Cited in
(10)- A Bayesian group selection with compositional responses for analysis of radiologic tumor proportions and their genomic determinants
- Towards a Bayesian decision theoretic analysis of contextual effect modifiers
- Bayesian polynomial regression models to fit multiple genetic models for quantitative traits
- Variable prioritization in nonlinear black box methods: a genetic association case study
- A Bayesian nonparametric method for model evaluation: application to genetic studies
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- Variable selection in Bayesian generalized linear‐mixed models: An illustration using candidate gene case‐control association studies
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