Oscillatory behavior of p53-Mdm2 system driven by transcriptional and translational time delays

DOI10.1142/S1793524520500345MaRDI QIDQ4984940zbMATH OpenOpenAlexFDO

Authors Chunyan Gao, Haihong Liu, Yuan Zhang, Fang Yan, Zengrong Liu

Publication date 21 April 2021

Published in International Journal of Biomathematics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1142/s1793524520500345

zbMATH Keywords

Hopf bifurcationp53-mdm2 pathwaystabilitytime delays

Mathematics Subject Classification ID

Bifurcation theory of functional-differential equations (34K18) Pathology, pathophysiology (92C32)

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Cites work

• Constructive role of noise in p53 regulatory network
• scientific article; zbMATH DE number 3743640 (Why is no real title available?)

Cited in

(18)

• From structure to dynamics: frequency tuning in the p53-Mdm2 network. I: Logical approach
• Dynamic behavior of the p53-Mdm2 core module under the action of drug Nutlin and dual delays
• Mathematical analysis of a generalised p53-Mdm2 protein gene expression model
• The role of time delays in P53 gene regulatory network stimulated by growth factor
• Theoretical analysis of the delay on the p53 micronetwork
• Analysis of a minimal model for p53 oscillations
• Oscillatory dynamics of p53 pathway in etoposide sensitive and resistant cell lines
• Spatio-Temporal Modelling of the p53–mdm2 Oscillatory System
• Theoretical study on the oscillation mechanism of p53-Mdm2 network
• Multiple time delays induced dynamics of p53 gene regulatory network
• P53-Mdm2 Loop Stability and Oscillatory Dynamics with Mdm2-Induced Delay Effect in P53
• Pattern Formation and Oscillations in Reaction–Diffusion Model with p53-Mdm2 Feedback Loop
• Oscillatory behaviors of delayed p53 regulatory network with microRNA 192 in DNA damage response
• Oscillatory expression and variability in p53 regulatory network
• Kinetic analysis of p53 gene network with time delays and PIDD
• Delay induced Hopf bifurcation and its control in a fractional p53 protein oscillator model
• Stability and bifurcation analysis of a simple delayed p53-Mdm2 gene network model with diffusion
• A dynamic P53-MDM2 model with time delay

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