A dynamic P53-MDM2 model with time delay

DOI10.1016/J.CHAOS.2005.08.206MaRDI QIDQ943292zbMATH OpenOpenAlexFDO

Authors Gh. I. Mihalaş, R. F. Horhat, Mihaela Neamtu, Dumitru Opris

Publication date 9 September 2008

Published in Chaos, Solitons and Fractals (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/math/0507055

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Dynamical systems in biology (37N25) Bifurcation theory of functional-differential equations (34K18)

Abstract: Specific activator and repressor transcription factors which bind to specific regulator DNA sequences, play an important role in gene activity control. Interactions between genes coding such transcription factors should explain the different stable or sometimes oscillatory gene activities characteristic for different tissues. Starting with the model P53-MDM2 described into [6] and the process described into [5] we developed a new model of this interaction. Choosing the delay as a bifurcation parameter we study the direction and stability of the bifurcating periodic solutions. Some numerical examples are finally given for justifying the theoretical results.

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Cites work

• scientific article; zbMATH DE number 3743640 (Why is no real title available?)
• Stability of limit cycles in a pluripotent stem cell dynamics model

Cited in

(11)

• Spatio-Temporal Modelling of the p53–mdm2 Oscillatory System
• A simple model of genetic oscillations through regulated degradation
• Spatio-temporal modelling of the Hes1 and p53-Mdm2 intracellular signalling pathways
• HOPF BIFURCATION ANALYSIS FOR A MATHEMATICAL MODEL OF P53-MDM2 INTERACTION
• Mathematical analysis of a generalised p53-Mdm2 protein gene expression model
• Oscillatory expression and variability in p53 regulatory network
• Analysis of a minimal model for p53 oscillations
• P53-Mdm2 Loop Stability and Oscillatory Dynamics with Mdm2-Induced Delay Effect in P53
• The dynamics of genetic control in the cell: the good and bad of being late
• Influence of the nuclear membrane, active transport, and cell shape on the Hes1 and p53-Mdm2 pathways: insights from spatio-temporal modelling
• Pattern Formation and Oscillations in Reaction–Diffusion Model with p53-Mdm2 Feedback Loop

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