A spatial physiological model for p53 intracellular dynamics

DOI10.1016/j.jtbi.2012.08.035zbMath1397.92185OpenAlexW2034835962WikidataQ44601322 ScholiaQ44601322MaRDI QIDQ1790847

Roberto Natalini, Luna Dimitrio, Jean Clairambault

Publication date: 4 October 2018

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://hal.inria.fr/hal-00726014/file/manuscript-reviewed_p53.pdf

zbMATH Keywords

partial differential equationsmathematical modelssignalling pathwaysp53intracellular dynamics

Mathematics Subject Classification ID

Bifurcation theory for ordinary differential equations (34C23) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Biochemistry, molecular biology (92C40) Cell biology (92C37)

Related Items (6)

Spatio-temporal models of synthetic genetic oscillators ⋮ Physiologically Structured Cell Population Dynamic Models with Applications to Combined Drug Delivery Optimisation in Oncology ⋮ Spatial-stochastic modelling of synthetic gene regulatory networks ⋮ Mathematical model for transport of DNA plasmids from the external medium up to the nucleus by electroporation ⋮ Dynamics of posttranslational modifications of p53 ⋮ Derivation and Application of Effective Interface Conditions for Continuum Mechanical Models of Cell Invasion through Thin Membranes

Cites Work

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• A spatial model of cellular molecular trafficking including active transport along microtubules
• Influence of the nuclear membrane, active transport, and cell shape on the Hes1 and p53-Mdm2 pathways: insights from spatio-temporal modelling
• Spatio-temporal modelling of the NF-\(\kappa\)B intracellular signalling pathway: the roles of diffusion, active transport, and cell geometry
• Spatio-Temporal Modelling of the p53–mdm2 Oscillatory System
• The Quasi-Steady-State Assumption: A Case Study in Perturbation
• Elements of applied bifurcation theory

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