Spatio-temporal modelling of the Hes1 and p53-Mdm2 intracellular signalling pathways
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Publication:1670650
DOI10.1016/J.JTBI.2010.12.016zbMATH Open1405.92085OpenAlexW2117931389WikidataQ44019888 ScholiaQ44019888MaRDI QIDQ1670650FDOQ1670650
Authors: Marc Sturrock, Alan J. Terry, Dimitris P. Xirodimas, Alastair M. Thompson, M. A. J. Chaplain 
Publication date: 6 September 2018
Published in: Journal of Theoretical Biology (Search for Journal in Brave)
Full work available at URL: https://doi.org/10.1016/j.jtbi.2010.12.016
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PDEs in connection with biology, chemistry and other natural sciences (35Q92) Cell biology (92C37) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)
Cites Work
- Models of genetic control by repression with time delays and spatial effects
- Genetic control models with diffusion and delays
- A spatial model of cellular molecular trafficking including active transport along microtubules
- Computational cell biology
- Dissecting the dynamics of the Hes1 genetic oscillator
- Interaction of spatial diffusion and delays in models of genetic control by repression
- Spatio-Temporal Modelling of the p53–mdm2 Oscillatory System
- From structure to dynamics: frequency tuning in the p53-Mdm2 network. I: Logical approach
- Oscillations and bistability in the stochastic model of p53 regulation
- A dynamic P53-MDM2 model with time delay
- From structure to dynamics: frequency tuning in the p53-Mdm2 network. II: Differential and stochastic approaches
Cited In (27)
- Oscillations in well-mixed, deterministic feedback systems: beyond ring oscillators
- Molecular crosstalk: notch can manipulate Hes1 and miR-9 behavior
- The role of dimerisation and nuclear transport in the Hes1 gene regulatory network
- Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network
- Spatial-stochastic modelling of synthetic gene regulatory networks
- Stability and Hopf bifurcation in a model of gene expression with distributed time delays
- The stability and Hopf bifurcation analysis of a gene expression model
- Spatio-Temporal Modelling of the p53–mdm2 Oscillatory System
- Autoregulation of transcription and translation: a qualitative analysis
- Spatio-temporal modelling of the NF-\(\kappa\)B intracellular signalling pathway: the roles of diffusion, active transport, and cell geometry
- Computational modelling of cancer development and growth: modelling at multiple scales and multiscale modelling
- Intracellular protein dynamics as a mathematical problem
- Mathematical analysis of a generalised p53-Mdm2 protein gene expression model
- The influence of nuclear compartmentalisation on stochastic dynamics of self-repressing gene expression
- Spatio-temporal models of synthetic genetic oscillators
- Justification of quasi-stationary approximation in models of gene expression of a self-regulating protein
- A minimal spatio-temporal model of the NF-\(\kappa \)B signalling pathway exhibits a range of behaviours
- Mean field analysis of a spatial stochastic model of a gene regulatory network
- Influence of the nuclear membrane, active transport, and cell shape on the Hes1 and p53-Mdm2 pathways: insights from spatio-temporal modelling
- Hopf bifurcation in a gene regulatory network model: molecular movement causes oscillations
- Hopf bifurcation analysis of a gene regulatory network mediated by small noncoding RNA with time delays and diffusion
- Mathematical model for transport of DNA plasmids from the external medium up to the nucleus by electroporation
- A spatial physiological model for p53 intracellular dynamics
- Mathematical modelling and analysis of the brassinosteroid and gibberellin signalling pathways and their interactions
- Mathematical modeling of the intracellular protein dynamics: the importance of active transport along microtubules
- Stability and Hopf bifurcation analysis of a gene expression model with diffusion and time delay
- A model of regulatory dynamics with threshold-type state-dependent delay
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