Oscillations and bistability in the stochastic model of p53 regulation

DOI10.1016/j.jtbi.2008.05.039zbMath1400.92200OpenAlexW2113126782WikidataQ53469954 ScholiaQ53469954MaRDI QIDQ1797507

Tomasz Lipniacki, Beata Hat, Krzysztof Puszynski

Publication date: 22 October 2018

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2008.05.039

zbMATH Keywords

stochastic simulationsmathematical modelingapoptosissignaling pathwaysp53Mdm2positive and negative feedbacksPTEN

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Biochemistry, molecular biology (92C40)

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Cites Work

• Intracellular delay limits cyclic changes in gene expression
• Transcriptional stochasticity in gene expression
• Modeling stochasticity in gene regulation: Characterization in the terms of the underlying distribution function