On p53 revival using system oriented drug dosage design

DOI10.1016/J.JTBI.2016.12.008MaRDI QIDQ2013685zbMATH OpenOpenAlexWikidataFDO

Authors Muhammad Haseeb, Shumaila Azam, Rizwan Azam, Mukhtar Ullah, Sahar Fazal, Aamer Iqbal Bhatti

Publication date 9 August 2017

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2016.12.008

zbMATH Keywords

cancerp53Mdm2NutlinPBK

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40)

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Cites work

• Oscillations and bistability in the stochastic model of p53 regulation
• Regulation of p53 by SIRNA in radiation treated cells: simulation studies

Cited in

(4)

• Effect of pharmacodynamical interaction between nutlin-3a and aspirin in the activation of p53
• Delay induced Hopf bifurcation and its control in a fractional p53 protein oscillator model
• Robust p53 recovery using chattering free sliding mode control and a gain-scheduled modified utkin observer
• Dynamic behavior of the p53-Mdm2 core module under the action of drug Nutlin and dual delays

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