On p53 revival using system oriented drug dosage design

DOI10.1016/J.JTBI.2016.12.008zbMATH Open1368.92052OpenAlexW2566769819WikidataQ48899654 ScholiaQ48899654MaRDI QIDQ2013685FDOQ2013685

Authors: Muhammad Haseeb, Shumaila Azam, Rizwan Azam, Mukhtar Ullah, Sahar Fazal, Aamer Iqbal Bhatti 

Publication date: 9 August 2017

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2016.12.008

Recommendations

• Dynamic behavior of the p53-Mdm2 core module under the action of drug Nutlin and dual delays
• Robust p53 recovery using chattering free sliding mode control and a gain-scheduled modified utkin observer
• Effect of pharmacodynamical interaction between nutlin-3a and aspirin in the activation of p53
• Mathematical modelling of p53 basal dynamics and DNA damage response
• Oscillations and bistability in the stochastic model of p53 regulation

zbMATH Keywords

cancerp53Mdm2NutlinPBK

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40)

Cites Work

• Oscillations and bistability in the stochastic model of p53 regulation
• Regulation of p53 by siRNA in radiation treated cells: Simulation studies

Cited In (4)

• Dynamic behavior of the p53-Mdm2 core module under the action of drug Nutlin and dual delays
• Delay induced Hopf bifurcation and its control in a fractional p53 protein oscillator model
• Robust p53 recovery using chattering free sliding mode control and a gain-scheduled modified utkin observer
• Effect of pharmacodynamical interaction between nutlin-3a and aspirin in the activation of p53

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