Regulation of p53 by SIRNA in radiation treated cells: simulation studies

DOI10.2478/V10006-012-0075-9MaRDI QIDQ5403413zbMATH OpenOpenAlexFDO

Authors Krzysztof Puszynski, Roman Jaksik, Andrzej Świerniak

Publication date 26 March 2014

Published in International Journal of Applied Mathematics and Computer Science (Search for Journal in Brave)

Full work available at URL https://doi.org/10.2478/v10006-012-0075-9

zbMATH Keywords

cancer cellscombined therapyintracellular mechanismsp53 signaling pathwaysmall interfering RNA (SIRNA)

Mathematics Subject Classification ID

Medical applications (general) (92C50) Control/observation systems governed by ordinary differential equations (93C15)

Recommendations

• Cellular responding DNA damage: An improved modeling of P53 gene regulatory networks under ion radiation (IR)
• Application of bifurcation theory and siRNA-based control signal to restore the proper response of cancer cells to DNA damage
• Oscillations and bistability in the stochastic model of p53 regulation
• Bystander effects and their implications for clinical radiation therapy: insights from multiscale \textit{in silico} experiments
• Mathematical modeling of the role of \textit{survivin} on dedifferentiation and radioresistance in cancer

Cites work

• scientific article; zbMATH DE number 2062254 (Why is no real title available?)
• Oscillations and bistability in the stochastic model of p53 regulation
• Planning identification experiments for cell signaling pathways: an NF\(\kappa \)B case study

Cited in

(5)

• On p53 revival using system oriented drug dosage design
• Application of bifurcation theory and siRNA-based control signal to restore the proper response of cancer cells to DNA damage
• Building the library of RNA 3D nucleotide conformations using the clustering approach
• Mathematical analysis of a generalised p53-Mdm2 protein gene expression model
• Cellular responding DNA damage: An improved modeling of P53 gene regulatory networks under ion radiation (IR)

This page was built for publication: Regulation of p53 by SIRNA in radiation treated cells: simulation studies

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q5403413)