Application of bifurcation theory and siRNA-based control signal to restore the proper response of cancer cells to DNA damage

DOI10.1016/J.JTBI.2016.08.017MaRDI QIDQ727152zbMATH OpenOpenAlexWikidataFDO

Authors Emilia Kozłowska, Krzysztof Puszynski

Publication date 6 December 2016

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Full work available at URL https://doi.org/10.1016/j.jtbi.2016.08.017

zbMATH Keywords

bifurcation theorysiRNAtransduction pathway

Mathematics Subject Classification ID

Medical applications (general) (92C50) Biochemistry, molecular biology (92C40) Cell biology (92C37)

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Cites work

• Elements of applied bifurcation theory
• Oscillations and bistability in the stochastic model of p53 regulation
• Regulation of p53 by SIRNA in radiation treated cells: simulation studies

Cited in

(6)

• Robust p53 recovery using chattering free sliding mode control and a gain-scheduled modified utkin observer
• Mathematical analysis of a generalised p53-Mdm2 protein gene expression model
• Construction of a Waddington-like landscape model that can guide clinical exploration of p53-dynamics-activating parameters in the face of divergent p53 dynamics
• Regulation of p53 by SIRNA in radiation treated cells: simulation studies
• Codimension-3 bifurcation in the p53 regulatory network model
• Mathematical modelling of core regulatory mechanism in p53 protein that activates apoptotic switch

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