Bystander effects and their implications for clinical radiation therapy: insights from multiscale \textit{in silico} experiments
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Publication:738646
DOI10.1016/J.JTBI.2016.04.010zbMATH Open1343.92130arXiv1407.0867OpenAlexW1491153233WikidataQ50665188 ScholiaQ50665188MaRDI QIDQ738646FDOQ738646
Authors: Gibin G. Powathil, Alastair J. Munro, Maciej Swat, M. A. J. Chaplain 
Publication date: 5 September 2016
Published in: Journal of Theoretical Biology (Search for Journal in Brave)
Abstract: Radiotherapy is a commonly used treatment for cancer and is usually given in varying doses. At low radiation doses relatively few cells die as a direct response to radiation but secondary radiation effects such as DNA mutation or bystander effects affect many cells. Consequently it is at low radiation levels where an understanding of bystander effects is essential in designing novel therapies with superior clinical outcomes. In this article, we use a hybrid multiscale mathematical model to study the direct effects of radiation as well as radiation-induced bystander effects on both tumour cells and normal cells. We show that bystander responses may play a major role in mediating radiation damage to cells at low-doses of radiotherapy, doing more damage than that due to direct radiation. The survival curves derived from our computational simulations showed an area of hyper-radiosensitivity at low-doses that are not obtained using a traditional radiobiological model.
Full work available at URL: https://arxiv.org/abs/1407.0867
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Cites Work
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Cited In (8)
- In silico nanodosimetry: new insights into nontargeted biological responses to radiation
- Effects of G2-checkpoint dynamics on low-dose hyper-radiosensitivity
- Predicting radiotherapy patient outcomes with real-time clinical data using mathematical modelling
- A model for radiation-induced bystander effects, with allowance for spatial position and the effects of cell turnover
- A reaction-diffusion model for radiation-induced bystander effects
- A simulation study of the radiation-induced bystander effect: modeling with stochastically defined signal reemission
- Regulation of p53 by SIRNA in radiation treated cells: simulation studies
- Models for the bystander effect in gradient radiation fields: range and signalling type
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