A Model for p53 Dynamics Triggered by DNA Damage

DOI10.1137/060653925MaRDI QIDQ5309765zbMATH OpenOpenAlexFDO

Authors Vijay Chickarmane, Animesh Ray, Herbert M. Sauro, A. Nadim

Publication date 2 October 2007

Published in SIAM Journal on Applied Dynamical Systems (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1137/060653925

zbMATH Keywords

Hopf bifurcationLangevinmathematical biologystochastic

Mathematics Subject Classification ID

Dynamical systems in biology (37N25) General biology and biomathematics (92B05)

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Cited in

(18)

• Decision making of the p53 network: death by integration
• From structure to dynamics: frequency tuning in the p53-Mdm2 network. II: Differential and stochastic approaches
• A spatial physiological model for p53 intracellular dynamics
• Oscillations and bistability in the stochastic model of p53 regulation
• Intrinsic noise and Hill dynamics in the p53 system
• Cellular responding DNA damage: An improved modeling of P53 gene regulatory networks under ion radiation (IR)
• Coupling switches and oscillators as a means to shape cellular signals in biomolecular systems
• A unified model for studying DNA damage-induced p53--Mdm2 interaction
• On the role of intrinsic noise on the response of the p53-Mdm2 module
• Codimension-3 bifurcation in the p53 regulatory network model
• Bifurcation and Potential Landscape of p53 Dynamics Depending on PDCD5 Level and ATM Degradation Rate
• Design, optimization and predictions of a coupled model of the cell cycle, circadian clock, DNA repair system, irinotecan metabolism and exposure control under temporal logic constraints
• Oscillatory behaviors of delayed p53 regulatory network with microRNA 192 in DNA damage response
• Modeling the p53-Mdm2 dynamics triggered by DNA damage
• Modeling hepatitis C virus protein and p53 interactions in hepatocytes: implications for carcinogenesis
• Disorder, oscillatory dynamics and state switching: the role of c-Myc
• Dynamics of p53 regulatory network in DNA damage response
• A dynamic P53-MDM2 model with time delay

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