Modeling the p53-Mdm2 dynamics triggered by DNA damage

DOI10.1007/S00332-024-10023-9MaRDI QIDQ6123648zbMATH OpenOpenAlexFDO

Authors Zirui Zhu, Yan Cong Xu, Xingbo Liu, Shigui Ruan

Publication date 6 April 2024

Published in Journal of Nonlinear Science (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s00332-024-10023-9

zbMATH Keywords

Bogdanov-Takens bifurcation of codimension 3cusp of limit cyclesDNA damage repairisola of limit cyclesp53-Mdm2 systemzero-Hopf bifurcation

Mathematics Subject Classification ID

Bifurcation theory for ordinary differential equations (34C23) Periodic solutions to ordinary differential equations (34C25) Homoclinic and heteroclinic solutions to ordinary differential equations (34C37) Population dynamics (general) (92D25)

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Cites work

• A Model for p53 Dynamics Triggered by DNA Damage
• Bifurcation and overexploitation in Rosenzweig-MacArthur model
• Codimension-3 bifurcation in the p53 regulatory network model
• Control of birhythmicity: a self-feedback approach
• Generic 3-parameter families of vector fields on the plane, unfolding a singularity with nilpotent linear part. The cusp case of codimension 3
• scientific article; zbMATH DE number 638936 (Why is no real title available?)
• Intrinsic noise and Hill dynamics in the p53 system
• Oscillatory behaviors of delayed p53 regulatory network with microRNA 192 in DNA damage response
• Snakes and isolas in non-reversible conservative systems
• Three Limit Cycles in a Leslie–Gower Predator-Prey Model with Additive Allee Effect
• Vectored immunoprophylaxis and cell-to-cell transmission in HIV dynamics

Cited in

(5)

• Asymptotic stability of delayed complex balanced reaction networks with non-mass action kinetics
• Global bifurcation dynamics in an SIRS model with nonlinear incidence and double exposure
• Decoding cancer dynamics: the role of miRNA in E2F/Myc networks and bifurcation points
• Stability and bifurcation analysis of a simple delayed p53-Mdm2 gene network model with diffusion
• Bifurcation analysis and control on the delayed gene regulatory models

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