A qualitative mathematical model of the immune response under the effect of stress

DOI10.1063/5.0055784zbMATH Open1465.92019arXiv2102.05512OpenAlexW3171078051MaRDI QIDQ5000837FDOQ5000837

Authors: Maria Elena Gonzalez Herrero, Christian Kuehn 

Publication date: 15 July 2021

Published in: Chaos: An Interdisciplinary Journal of Nonlinear Science (Search for Journal in Brave)

Abstract: In the last decades, the interest to understand the connection between brain and body has grown notably. For example, in psychoneuroimmunology many studies associate stress, arising from many different sources and situations, to changes in the immune system from the medical or immunological point of view as well as from the biochemical one. In this paper we identify important behaviours of this interplay between the immune system and stress from medical studies and seek to represent them qualitatively in a paradigmatic, yet simple, mathematical model. To that end we develop a differential equation model with two equations for infection level and immune system, which integrates the effects of stress as an additional parameter. We are able to reproduce a stable healthy state for little stress, an oscillatory state between healthy and infected states for high stress, and a "burn-out" or stable sick state for extremely high stress. The mechanism between the different dynamics is controlled by two saddle-node in cycle (SNIC) bifurcations. Furthermore, our model is able to capture an induced infection upon dropping from moderate to low stress, and it predicts increasing infection periods upon increasing before eventually reaching a burn-out state.

Full work available at URL: https://arxiv.org/abs/2102.05512

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Mathematics Subject Classification ID

Physiology (general) (92C30) Neural biology (92C20)

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• A qualitative mathematical model of the immune response under the effect of stress

Cited In (3)

• A mathematical model of the immune and neuroendocrine systems mutual regulation under the technogenic chemical factors impact
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• A qualitative mathematical model of the immune response under the effect of stress

Uses Software

• MATCONT

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