Mean field limits of particle-based stochastic reaction-diffusion models
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Publication:5024686
DOI10.1137/20M1365600zbMATH Open1482.35115arXiv2003.11868OpenAlexW3013862997MaRDI QIDQ5024686FDOQ5024686
Authors: Samuel A. Isaacson, Jingwei Ma, Konstantinos Spiliopoulos 
Publication date: 27 January 2022
Published in: SIAM Journal on Mathematical Analysis (Search for Journal in Brave)
Abstract: Particle-based stochastic reaction-diffusion (PBSRD) models are a popular approach for studying biological systems involving both noise in the reaction process and diffusive transport. In this work we derive coarse-grained deterministic partial integro-differential equation (PIDE) models that provide a mean field approximation to the volume reactivity PBSRD model, a model commonly used for studying cellular processes. We formulate a weak measure-valued stochastic process (MVSP) representation for the volume reactivity PBSRD model, demonstrating for a simplified but representative system that it is consistent with the commonly used Doi Fock Space representation of the corresponding forward equation. We then prove the convergence of the general volume reactivity model MVSP to the mean field PIDEs in the large-population (i.e. thermodynamic) limit.
Full work available at URL: https://arxiv.org/abs/2003.11868
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