Mean field limits of particle-based stochastic reaction-diffusion models
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Publication:5024686
chemical reaction networksmean field approximationparticle modelscoarse-grained deterministic partial integro-differential equation
Central limit and other weak theorems (60F05) Reaction-diffusion equations (35K57) Integro-partial differential equations (35R09) PDEs with randomness, stochastic partial differential equations (35R60) Interacting particle systems in time-dependent statistical mechanics (82C22) Stochastic methods (Fokker-Planck, Langevin, etc.) applied to problems in time-dependent statistical mechanics (82C31) Theoretical approximation in context of PDEs (35A35)
Abstract: Particle-based stochastic reaction-diffusion (PBSRD) models are a popular approach for studying biological systems involving both noise in the reaction process and diffusive transport. In this work we derive coarse-grained deterministic partial integro-differential equation (PIDE) models that provide a mean field approximation to the volume reactivity PBSRD model, a model commonly used for studying cellular processes. We formulate a weak measure-valued stochastic process (MVSP) representation for the volume reactivity PBSRD model, demonstrating for a simplified but representative system that it is consistent with the commonly used Doi Fock Space representation of the corresponding forward equation. We then prove the convergence of the general volume reactivity model MVSP to the mean field PIDEs in the large-population (i.e. thermodynamic) limit.
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