Dynamics of Dirac concentrations in the evolution of quantitative alleles with sexual reproduction

DOI10.1088/1361-6544/AC91BBzbMATH Open1501.35409arXiv2111.14814OpenAlexW3216795736MaRDI QIDQ5042389FDOQ5042389

Authors:

Publication date: 19 October 2022

Published in: Nonlinearity (Search for Journal in Brave)

Abstract: A proper understanding of the links between varying gene expression levels and complex trait adaptation is still lacking, despite recent advances in sequencing techniques leading to new insights on their importance in some evolutionary processes. This calls for extensions of the continuum-of-alleles framework first introduced by Kimura (1965) that bypass the classical Gaussian approximation. Here, we propose a novel mathematical framework to study the evolutionary dynamics of quantitative alleles for sexually reproducing populations under natural selection and competition through an integro-differential equation. It involves a new reproduction operator which allows to use techniques based on the maximum principle, unlike the infinitesimal model operator used in other studies with sexual reproduction. In an asymptotic regime where initially the population has a small phenotypic variance, we analyse the long-term dynamics of the phenotypic distributions according to the methodology of small variance (Diekmann et al. 2005). Under some assumptions on the limit equation, we show that the population remains monomorphic, that is the phenotypic distribution remains concentrated as a moving Dirac mass. Moreover, in the case of a monomorphic distribution we derive a canonical equation describing the dynamics of the dominant alleles.

Full work available at URL: https://arxiv.org/abs/2111.14814

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zbMATH Keywords

asymptotic analysisintegro-differential equationevolutionary biology dynamicsnon-linear non-local operator

Mathematics Subject Classification ID

Problems related to evolution (92D15) Dynamical systems in biology (37N25) Population dynamics (general) (92D25) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Integro-partial differential equations (35R09) Computational methods for problems pertaining to biology (92-08)

Cites Work

• A rigorous model study of the adaptive dynamics of Mendelian diploids
• The dynamics of adaptation: An illuminating example and a Hamilton--Jacobi approach
• A stochastic model concerning the maintenance of genetic variability in quantitative characters.
• Title not available (Why is that?)
• A Hamilton-Jacobi approach to characterize the evolutionary equilibria in heterogeneous environments
• Dirac concentrations in Lotka-Volterra parabolic PDEs
• Concentration in Lotka-Volterra parabolic or integral equations: a general convergence result
• Dynamics of sexual populations structured by a space variable and a phenotypical trait
• The infinitesimal model: definition, derivation, and implications
• Long time evolutionary dynamics of phenotypically structured populations in time-periodic environments
• Central limit theorems for pedigrees
• Commentary: ``Fisher's infinitesimal model: a story for the ages
• Asymptotic analysis of a quantitative genetics model with nonlinear integral operator
• Front propagation of a sexual population with evolution of dispersion: a formal analysis

Cited In (5)

• Evolutionary dynamics of complex traits in sexual populations in a heterogeneous environment: how normal?
• Evolutionary dynamics of a quantitative trait in a finite asexual population
• Adaptation of a quantitative trait to a changing environment: new analytical insights on the asexual and infinitesimal sexual models
• A dynamical analysis of allele frequencies in populations evolving under assortative mating and mutations
• On the Fisher infinitesimal model without variability

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