Action potential propagation and block in a model of atrial tissue with myocyte-fibroblast coupling
From MaRDI portal
Publication:5044948
DOI10.1093/IMAMMB/DQAA014zbMATH Open1501.92008arXiv2012.05368OpenAlexW3120185029WikidataQ104792515 ScholiaQ104792515MaRDI QIDQ5044948FDOQ5044948
Authors: Peter Mortensen, Hao Gao, Radostin D. Simitev 
Publication date: 3 November 2022
Published in: Mathematical Medicine and Biology: A Journal of the IMA (Search for Journal in Brave)
Abstract: The electrical coupling between myocytes and fibroblasts and the spacial distribution of fibroblasts within myocardial tissues are significant factors in triggering and sustaining cardiac arrhythmias but their roles are poorly understood. This article describes both direct numerical simulations and an asymptotic theory of propagation and block of electrical excitation in a model of atrial tissue with myocyte-fibroblast coupling. In particular, three idealised fibroblast distributions are introduced: uniform distribution, fibroblast barrier and myocyte strait, all believed to be constituent blocks of realistic fibroblast distributions. Primary action potential biomarkers including conduction velocity, peak potential and triangulation index are estimated from direct simulations in all cases. Propagation block is found to occur at certain critical values of the parameters defining each idealised fibroblast distribution and these critical values are accurately determined. An asymptotic theory proposed earlier is extended and applied to the case of a uniform fibroblast distribution. Biomarker values are obtained from hybrid analytical-numerical solutions of coupled fast-time and slow-time periodic boundary value problems and compare well to direct numerical simulations. The boundary of absolute refractoriness is determined solely by the fast-time problem and is found to depend on the values of the myocyte potential and on the slow inactivation variable of the sodium current ahead of the propagating pulse. In turn, these quantities are estimated from the slow-time problem using a regular perturbation expansion to find the steady state of the coupled myocyte-fibroblast kinetics. The asymptotic theory gives a simple analytical expression that captures with remarkable accuracy the block of propagation in the presence of fibroblasts.
Full work available at URL: https://arxiv.org/abs/2012.05368
Recommendations
- Addendum: Action potential propagation and block in a model of atrial tissue with myocyte-fibroblast coupling
- Excitation-contraction coupling between human atrial myocytes with fibroblasts and stretch activated channel current: a simulation study
- Simulation of atrial fibrosis using coupled myocyte-fibroblast cellular and human atrial models
- Existence of excitation waves for a collection of cardiomyocytes electrically coupled to fibroblasts
- Effects of \(\mathrm{Na}^+\) current and mechanogated channels in myofibroblasts on myocyte excitability and repolarization
Physiology (general) (92C30) Asymptotic approximations, asymptotic expansions (steepest descent, etc.) (41A60) Asymptotic properties of solutions to ordinary differential equations (34D05)
Cited In (11)
- Rhythms of high-grade block in an ionic model of a strand of regionally ischemic ventricular muscle
- Simulation of atrial fibrosis using coupled myocyte-fibroblast cellular and human atrial models
- Spontaneous activation under atrial fibrosis: a model using complex order derivatives
- Effects of \(\mathrm{Na}^+\) current and mechanogated channels in myofibroblasts on myocyte excitability and repolarization
- Excitation-contraction coupling between human atrial myocytes with fibroblasts and stretch activated channel current: a simulation study
- Modeling triggered cardiac activity: An analysis of the interactions between potassium blockade, rhythm pauses, and cellular coupling
- Ephaptic coupling of cardiac cells through the junctional electric potential
- Addendum: Action potential propagation and block in a model of atrial tissue with myocyte-fibroblast coupling
- Existence of excitation waves for a collection of cardiomyocytes electrically coupled to fibroblasts
- PROGRESS AND GAPS IN UNDERSTANDING THE ELECTROPHYSIOLOGICAL PROPERTIES OF MORPHOLOGICALLY NORMAL CELLS FROM THE CARDIAC ATRIOVENTRICULAR NODE
- Remodelling of cellular excitation (reaction) and intercellular coupling (diffusion) by chronic atrial fibrillation represented by a reaction-diffusion system
This page was built for publication: Action potential propagation and block in a model of atrial tissue with myocyte-fibroblast coupling
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q5044948)
