Immersed boundary approach to biofilm spread on surfaces
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Abstract: We propose a computational framework to study the growth and spread of bacterial biofilms on interfaces, as well as the action of antibiotics on them. Bacterial membranes are represented by boundaries immersed in a fluid matrix and subject to interaction forces. Growth, division and death of bacterial cells follow dynamic energy budget rules, in response to variations in environmental concentrations of nutrients, toxicants and substances released by the cells. In this way, we create, destroy and enlarge boundaries, either spherical or rod-like. Appropriate forces represent details of the interaction between cells, and the interaction with the environment. Numerical simulations illustrate the evolution of top views and diametral slices of small biofilm seeds, as well as the action of antibiotics. We show that cocktails of antibiotics targeting active and dormant cells can entirely eradicate a biofilm.
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Cites work
- A simple 2D biofilm model yields a variety of morphological features
- A single-cell-based model of multicellular growth using the immersed boundary method
- An immersed boundary framework for modelling the growth of individual cells: an application to the early tumour development
- An immersed boundary method for simulating a single axisymmetric cell growth and division
- Dynamic energy budget approach to evaluate antibiotic effects on biofilms
- scientific article; zbMATH DE number 3269388 (Why is no real title available?)
- Material modeling of biofilm mechanical properties
- Modeling biofilm processes using the immersed boundary method
- Simulating Biofilm Deformation and Detachment with the Immersed Boundary Method
- The immersed boundary method
- Variable viscosity and density biofilm simulations using an immersed boundary method, part II: Experimental validation and the heterogeneous rheology-IBM
Cited in
(11)- Dynamic energy budget approach to evaluate antibiotic effects on biofilms
- Hybrid model of bacterial biofilm growth
- Modeling biofilm processes using the immersed boundary method
- Variable Viscosity and Density Biofilm Simulations using an Immersed Boundary Method, Part I: Numerical Scheme and Convergence Results
- A novel model for biofilm growth and its resolution by using the hybrid immersed interface-level set method
- Simulating Biofilm Deformation and Detachment with the Immersed Boundary Method
- Immersed Boundary Models of Biofilm Spread
- Two-fluid variable length model for cell crawling
- Driving biofilms to finite time extinction by antibiotic cocktails
- Well posedness of fluid-solid mixture models for biofilm spread
- Theoretical study on the bactericidal nature of nanopatterned surfaces
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