Immersed boundary approach to biofilm spread on surfaces
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Publication:5065174
Abstract: We propose a computational framework to study the growth and spread of bacterial biofilms on interfaces, as well as the action of antibiotics on them. Bacterial membranes are represented by boundaries immersed in a fluid matrix and subject to interaction forces. Growth, division and death of bacterial cells follow dynamic energy budget rules, in response to variations in environmental concentrations of nutrients, toxicants and substances released by the cells. In this way, we create, destroy and enlarge boundaries, either spherical or rod-like. Appropriate forces represent details of the interaction between cells, and the interaction with the environment. Numerical simulations illustrate the evolution of top views and diametral slices of small biofilm seeds, as well as the action of antibiotics. We show that cocktails of antibiotics targeting active and dormant cells can entirely eradicate a biofilm.
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Cites work
- scientific article; zbMATH DE number 3269388 (Why is no real title available?)
- A simple 2D biofilm model yields a variety of morphological features
- A single-cell-based model of multicellular growth using the immersed boundary method
- An immersed boundary framework for modelling the growth of individual cells: an application to the early tumour development
- An immersed boundary method for simulating a single axisymmetric cell growth and division
- Dynamic energy budget approach to evaluate antibiotic effects on biofilms
- Material modeling of biofilm mechanical properties
- Modeling biofilm processes using the immersed boundary method
- Simulating Biofilm Deformation and Detachment with the Immersed Boundary Method
- The immersed boundary method
- Variable viscosity and density biofilm simulations using an immersed boundary method, part II: Experimental validation and the heterogeneous rheology-IBM
Cited in
(9)- Variable Viscosity and Density Biofilm Simulations using an Immersed Boundary Method, Part I: Numerical Scheme and Convergence Results
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- Theoretical study on the bactericidal nature of nanopatterned surfaces
- Two-fluid variable length model for cell crawling
- Immersed Boundary Models of Biofilm Spread
- Simulating Biofilm Deformation and Detachment with the Immersed Boundary Method
- Hybrid model of bacterial biofilm growth
- Dynamic energy budget approach to evaluate antibiotic effects on biofilms
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