An optimal mass transport method for random genetic drift
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Asymptotic behavior of solutions to PDEs (35B40) Blow-up in context of PDEs (35B44) PDEs with randomness, stochastic partial differential equations (35R60) Newton-type methods (49M15) Finite difference methods for initial value and initial-boundary value problems involving PDEs (65M06) Protein sequences, DNA sequences (92D20) Population dynamics (general) (92D25)
Abstract: We propose and analyze an optimal mass transport method for a random genetic drift problem driven by a Moran process under weak-selection. The continuum limit, formulated as a reaction-advection-diffusion equation known as the Kimura equation, inherits degenerate diffusion from the discrete stochastic process that conveys to the blow-up into Dirac-delta singularities hence brings great challenges to both the analytical and numerical studies. The proposed numerical method can quantitatively capture to the fullest possible extent the development of Dirac-delta singularities for genetic segregation on one hand, and preserves several sets of biologically relevant and computationally favored properties of the random genetic drift on the other. Moreover, the numerical scheme exponentially converges to the unique numerical stationary state in time at a rate independent of the mesh size up to a mesh error. Numerical evidence is given to illustrate and support these properties, and to demonstrate the spatio-temporal dynamics of random generic drift.
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Cited in
(7)- Behavior of different numerical schemes for random genetic drift
- Numerical complete solution for random genetic drift by energetic variational approach
- Numerical method for multi-alleles genetic drift problem
- Hidden Dissipation and Convexity for Kimura Equations
- On a continuum model for random genetic drift: a dynamic boundary condition approach
- Exploring the evolution of altruistic punishment with a PDE model of cultural multilevel selection
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