Efficient design and analysis of biospecimens with measurements subject to detection limit

DOI10.1002/BIMJ.200610266MaRDI QIDQ5122873zbMATH OpenOpenAlexWikidataFDO

Authors Albert Vexler, Aiyi Liu, Enrique F. Schisterman

Publication date 24 September 2020

Published in Biometrical Journal (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/bimj.200610266

zbMATH Keywords

detection limitinformation matrixrandom samplingpooling designtruncated/censored data

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

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(8)

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• On optimization of bio‐probes
• A combined efficient design for biomarker data subject to a limit of detection due to measuring instrument sensitivity
• An efficient design strategy for logistic regression using outcome-and covariate-dependent pooling of biospecimens prior to assay
• Nonparametric-likelihood inference based on cost-effectively-sampled-data
• Single-index regression for pooled biomarker data
• Pooling designs for outcomes under a Gaussian random effects model
• Cost-efficient designs based on linearly associated biomarkers

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