Covariate-adaptive optimization in online clinical trials

DOI10.1287/OPRE.2018.1818MaRDI QIDQ5129185zbMATH OpenOpenAlexWikidataFDO

Authors Nikita Korolko, Alexander M. Weinstein, Dimitris Bertsimas

Publication date 26 October 2020

Published in Operations Research (Search for Journal in Brave)

Full work available at URL https://semanticscholar.org/paper/725a2d0a269dcca8bf26e14e063aaa9d593ab5e9

zbMATH Keywords

clinical trialsstatistical powerrobust optimizationmixed integer optimizationonline allocationcovariate-adaptive randomization

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50) Sampling theory, sample surveys (62D05) Optimal statistical designs (62K05)

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Cites work

• A finite selection model for experimental design of the health insurance study
• Agnostic notes on regression adjustments to experimental data: reexamining Freedman's critique
• Forcing a sequential experiment to be balanced
• Handling covariates in the design of clinical trials
• Matching on-the-fly: sequential allocation with higher power and efficiency
• Modeling survival data: extending the Cox model
• Optimal multivariate matching before randomization
• Optimum biased coin designs for sequential clinical trials with prognostic factors
• Rerandomization to improve covariate balance in experiments
• Robust Solutions of Uncertain Quadratic and Conic-Quadratic Problems
• The central role of the propensity score in observational studies for causal effects
• The covariate-adaptive biased coin design for balancing clinical trials in the presence of prognostic factors
• The power of optimization over randomization in designing experiments involving small samples
• Theory and applications of robust optimization

Cited in

(3)

• Fractional 0-1 programs: links between mixed-integer linear and conic quadratic formulations
• A matching procedure for sequential experiments that iteratively learns which covariates improve power
• Pair-Switching Rerandomization

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