Covariate-adaptive optimization in online clinical trials

DOI10.1287/OPRE.2018.1818zbMATH Open1457.62335OpenAlexW2947517542WikidataQ120697922 ScholiaQ120697922MaRDI QIDQ5129185FDOQ5129185

Authors: Nikita Korolko, Alexander M. Weinstein, Dimitris Bertsimas 

Publication date: 26 October 2020

Published in: Operations Research (Search for Journal in Brave)

Full work available at URL: https://semanticscholar.org/paper/725a2d0a269dcca8bf26e14e063aaa9d593ab5e9

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zbMATH Keywords

clinical trialsstatistical powerrobust optimizationmixed integer optimizationonline allocationcovariate-adaptive randomization

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50) Sampling theory, sample surveys (62D05) Optimal statistical designs (62K05)

Cites Work

• Agnostic notes on regression adjustments to experimental data: reexamining Freedman's critique
• Modeling survival data: extending the Cox model
• The central role of the propensity score in observational studies for causal effects
• A finite selection model for experimental design of the health insurance study
• The power of optimization over randomization in designing experiments involving small samples
• Rerandomization to improve covariate balance in experiments
• Theory and applications of robust optimization
• The covariate-adaptive biased coin design for balancing clinical trials in the presence of prognostic factors
• Optimum biased coin designs for sequential clinical trials with prognostic factors
• Forcing a sequential experiment to be balanced
• Handling covariates in the design of clinical trials
• Robust Solutions of Uncertain Quadratic and Conic-Quadratic Problems
• Optimal multivariate matching before randomization
• Matching on-the-fly: sequential allocation with higher power and efficiency

Cited In (3)

• Fractional 0-1 programs: links between mixed-integer linear and conic quadratic formulations
• A matching procedure for sequential experiments that iteratively learns which covariates improve power
• Pair-Switching Rerandomization

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