Nonparametric Bayesian instrumental variable analysis: evaluating heterogeneous effects of coronary arterial access site strategies

DOI10.1080/01621459.2019.1688663zbMATH Open1452.62789arXiv1804.08055OpenAlexW3098796344WikidataQ126837873 ScholiaQ126837873MaRDI QIDQ5146014FDOQ5146014

Authors: Samrachana Adhikari, Sherri Rose, Sharon-Lise Normand 

Publication date: 22 January 2021

Published in: Journal of the American Statistical Association (Search for Journal in Brave)

Abstract: Percutaneous coronary interventions (PCIs) are nonsurgical procedures to open blocked blood vessels to the heart, frequently using a catheter to place a stent. The catheter can be inserted into the blood vessels using an artery in the groin or an artery in the wrist. Because clinical trials have indicated that access via the wrist may result in fewer post procedure complications, shortening the length of stay, and ultimately cost less than groin access, adoption of access via the wrist has been encouraged. However, patients treated in usual care are likely to differ from those participating in clinical trials, and there is reason to believe that the effectiveness of wrist access may differ between males and females. Moreover, the choice of artery access strategy is likely to be influenced by patient or physician unmeasured factors. To study the effectiveness of the two artery access site strategies on hospitalization charges, we use data from a state-mandated clinical registry including 7,963 patients undergoing PCI. A hierarchical Bayesian likelihood-based instrumental variable analysis under a latent index modeling framework is introduced to jointly model outcomes and treatment status. Our approach accounts for unobserved heterogeneity via a latent factor structure, and permits nonparametric error distributions with Dirichlet process mixture models. Our results demonstrate that artery access in the wrist reduces hospitalization charges compared to access in the groin, with higher mean reduction for male patients.

Full work available at URL: https://arxiv.org/abs/1804.08055

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zbMATH Keywords

selection biasheterogeneous treatment effectsPCIDirichlet process mixture priorshospitalization chargesradial versus femoral arterial access

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites Work

• Bayesian data analysis.
• Identification of Causal Effects Using Instrumental Variables
• A Bayesian analysis of some nonparametric problems
• Assessing the effect of an influenza vaccine in an encouragement design
• Regression and weighting methods for causal inference using instrumental variables
• Bootstrap Tests for Distributional Treatment Effects in Instrumental Variable Models
• Gibbs Sampling Methods for Stick-Breaking Priors
• Marginal and Nested Structural Models Using Instrumental Variables
• Independence, Monotonicity, and Latent Index Models: An Equivalence Result
• Bayesian analysis of cross-section and clustered data treatment models
• Bayesian treatment effects models with variable selection for panel outcomes with an application to earnings effects of maternity leave
• Treatment Effects: A Bayesian Perspective
• Estimation of Treatment Effects in Randomized Trials With Non-Compliance and a Dichotomous Outcome

Cited In (2)

• The how and why of Bayesian nonparametric causal inference
• Causal inference under mis-specification: adjustment based on the propensity score (with discussion)

Uses Software

• DPpackage
• BayesDA

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